- New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis
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Han CC, Wan FS
- KMID: 2429813
- J Breast Cancer.
- 2018 Dec;21(4):354-362.
- doi: 10.4048/jbc.2018.21.e51
Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To... -
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- Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases
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Yi HS
- KMID: 2441677
- Endocrinol Metab.
- 2019 Mar;34(1):39-46.
- doi: 10.3803/EnM.2019.34.1.39
The signaling network of the mitochondrial unfolded protein response (UPR(mt)) and mitohormesis is a retrograde signaling pathway through which mitochondria-to-nucleus communication occurs in organisms. Recently, it has been shown that... -
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- Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer
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Minakshi R, Rahman S, Jan AT, Archana A, Kim J
- KMID: 2396794
- Exp Mol Med.
- 2017 Nov;49(11):e389.
- doi: 10.1038/emm.2017.215
The endoplasmic reticulum (ER) is an important subcellular organelle that is involved in numerous activities required to achieve and maintain functional proteins in addition to its role in the biosynthesis... -
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- Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
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Ali I, Shah SZ, Jin Y, Li ZS, Ullah O, Fang NZ
- KMID: 2412581
- J Vet Sci.
- 2017 Mar;18(1):1-9.
- doi: 10.4142/jvs.2017.18.1.1
Excessive production of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-mediated responses are critical to embryonic development in the challenging in vitro environment. ROS production increases during early embryonic... -
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- Endoplasmic reticulum stress in periimplantation embryos
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Michalak M, Gye MC
- KMID: 1800419
- Clin Exp Reprod Med.
- 2015 Mar;42(1):1-7.
- doi: 10.5653/cerm.2015.42.1.1
Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is... -
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- Obesity and ER Stress
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Koo SH
- KMID: 2270933
- Korean J Obes.
- 2011 Jun;20(2):45-50.
Endoplastic reticulum (ER) is one of the cellular organelle found in all eukaryotes. It plays a critical role in the protein folding, lipid and sterol biosynthesis, and the storage of... -
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- Endoplasmic Reticulum Stress and the Related Signaling Networks in Severe Asthma
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Kim SR, Lee YC
- KMID: 2365538
- Allergy Asthma Immunol Res.
- 2015 Mar;7(2):106-117.
- doi: 10.4168/aair.2015.7.2.106
The endoplasmic reticulum (ER) is a specialized organelle that plays a central role in biosynthesis, correct protein folding, and posttranslational modifications of secretory and membrane proteins. Loss of homeostasis in... -
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- Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders
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Muneer A, Shamsher Khan RM
- KMID: 2432250
- Chonnam Med J.
- 2019 Jan;55(1):8-19.
- doi: 10.4068/cmj.2019.55.1.8
The Endoplasmic reticulum (ER), an indispensable sub-cellular component of the eukaryotic cell carries out essential functions, is critical to the survival of the organism. The chaperone proteins and the folding... -
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- Role of Endoplasmic Reticulum Stress in Rheumatoid Arthritis Pathogenesis
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Park YJ, Yoo SA, Kim WU
- KMID: 1796908
- J Korean Med Sci.
- 2014 Jan;29(1):2-11.
- doi: 10.3346/jkms.2014.29.1.2
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by abnormal proliferation of synoviocytes, leukocyte infiltration, and angiogenesis. The endoplasmic reticulum (ER) is the site of biosynthesis for all secreted... -
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- Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance
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Lee JM
- KMID: 2368524
- Diabetes Metab J.
- 2017 Feb;41(1):10-19.
- doi: 10.4093/dmj.2017.41.1.10
Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have... -
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- Effect of Exercise Intensity on Unfolded Protein Response in Skeletal Muscle of Rat
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Kim K, Kim YH, Lee SH, Jeon MJ, Park SY, Doh KO
- KMID: 2285512
- Korean J Physiol Pharmacol.
- 2014 Jun;18(3):211-216.
- doi: 10.4196/kjpp.2014.18.3.211
Endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and mitochondrial biogenesis were assessed following varying intensities of exercise training. The animals were randomly assigned to receive either low- (LIT, n=7)... -
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- miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells
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Cho YM, Kim TM, Kim DH, Kim DH, Jeong SW, Kwon OJ
- KMID: 2361513
- Exp Mol Med.
- 2016 Apr;48(4):e226.
- doi: 10.1038/emm.2016.3
Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors. We have previously demonstrated that Wnt10b transcription during adipogenesis is negatively regulated by... -
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- Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease
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Oh CM, Ryu D, Cho S, Jang Y
- KMID: 2471778
- Korean Circ J.
- 2020 May;50(5):395-405.
- doi: 10.4070/kcj.2019.0416
Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP... -
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- Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells
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Thomas SS, Park S, Cha YS, Kim KA
- KMID: 2444941
- J Nutr Health.
- 2019 Apr;52(2):176-184.
- doi: 10.4163/jnh.2019.52.2.176
PURPOSE: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The... -
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- Activation of AMP-Activated Protein Kinase Attenuates Tumor Necrosis Factor-alpha-Induced Lipolysis via Protection of Perilipin in 3T3-L1 Adipocytes
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Hong SW, Lee J, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY
- KMID: 2384254
- Endocrinol Metab.
- 2014 Dec;29(4):553-560.
- doi: 10.3803/EnM.2014.29.4.553
BACKGROUND: Tumor necrosis factor (TNF)-alpha and AMP-activated protein kinase (AMPK) are known to stimulate and repress lipolysis in adipocytes, respectively; however, the mechanisms regulating these processes have not been completely... -
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- Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease
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Kim YJ, Chang SY, Ko HJ
- KMID: 2284876
- Intest Res.
- 2015 Apr;13(2):105-111.
- doi: 10.5217/ir.2015.13.2.105
Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal... -
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- Involvement of Orai1 in tunicamycin-induced endothelial dysfunction
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Yang H, Xue Y, Kuang S, Zhang M, Chen J, Liu L, Shan Z, Lin Q, Li X, Yang M, Zhou H, Rao F, Deng C
- KMID: 2438083
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):95-102.
- doi: 10.4196/kjpp.2019.23.2.95
Endoplasmic reticulum (ER) stress is mediated by disturbance of Ca²⺠homeostasis. The store-operated calcium (SOC) channel is the primary Ca²⺠channel in non-excitable cells, but its participation in agent-induced ER... -
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- Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction
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Choi JH, Choi AY, Yoon H, Choe W, Yoon KS, Ha J, Yeo EJ, Kang I
- KMID: 1115265
- Exp Mol Med.
- 2010 Dec;42(12):811-822.
- doi: 10.3858/emm.2010.42.12.084
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases,... -
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