Korean Circ J.  2020 May;50(5):395-405. 10.4070/kcj.2019.0416.

Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease

Affiliations
  • 1Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
  • 2Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
  • 3Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon, Korea.
  • 4Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea.
  • 5Division of Cardiovascular medicine, Department of Internal medicine, Dankook University College of Medicine, Dankook University Hospital, Cheonan, Korea.
  • 6Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. JANGYS1212@yuhs.ac

Abstract

Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondrial dysfunction is the root cause for developing heart failure. Therefore, maintenance of mitochondrial quality control (MQC) is an essential process for cardiovascular homeostasis and cardiac health. In this review, we describe the major mechanisms of MQC system, such as mitochondrial unfolded protein response and mitophagy. Moreover, we describe the results of MQC failure in cardiac mitochondria. Furthermore, we discuss the prospects of 2 drug candidates, urolithin A and spermidine, for restoring mitochondrial homeostasis to treat CVD.

Keyword

Mitochondrial quality control; Heart; Urolithin A; Spermidine

MeSH Terms

Adenosine Triphosphate
Cardiovascular Diseases*
Cause of Death
Heart Failure
Heart*
Homeostasis
Mitochondria
Mitochondrial Degradation
Organelles
Quality Control*
Spermidine
Unfolded Protein Response
Adenosine Triphosphate
Spermidine
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