Korean J Pediatr Hematol Oncol.  2005 Apr;12(1):108-113.

Acute Lymphoblastic Leukemia with Chromosomal Translocation t (5; 14) (q31; q32) and Hypereosinophilia in a Child

• Lee KA
• Lee JS
• Sin KS
• Bae IH
• Lee SH
• Park HJ

Abstract

Hypereosinophilia has been associated with a variety of underlying disorders such as parasitic, fungal and mycobacterial infections, allergic disorders, collagen vascular diseases, or hypereosinophilic syndrome (HES). The association of acute lymphoblastic leukemia (ALL) and symptomatic eosinophilia is rare and only a few cases have been reported. HES probably occurs in less than 1% of all patients with ALL. The chromosomal translocation t (5; 14) (q31; q32) was cloned at the molecular level in ALL with eosinophilia. This translocation joined the immunoglobulin heavy chain region to the promoter region of the interleukin-3 (IL-3) gene in opposite transcriptional orientation. The IL-3 gene translocated with the immunoglobulin heavy chain gene may play a central role in the pathogenesis of this leukemia and the associated eosinophilia. We describe a 8-year-old boy who presented with hypereosinophilia and concurrent ALL with t (5; 14).

Keyword

Hypereosinophilia; Acute lymphoblastic leukemia; t (5; 14) (q31; q32)

MeSH Terms

Child*
Clone Cells
Collagen
Eosinophilia
Humans
Hypereosinophilic Syndrome
Immunoglobulin Heavy Chains
Interleukin-3
Leukemia
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Promoter Regions, Genetic
Translocation, Genetic*
Vascular Diseases
Collagen
Immunoglobulin Heavy Chains
Interleukin-3