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Regulation of Osteoclast Differentiation by Cytokine Networks

Amarasekara DS, Yun H, Kim S, Lee N, Kim H, Rho J

Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand...
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The Role of Cytokines in Allergy

Lee CH

  • KMID: 2131694
  • J Rhinol.
  • 1998 May;5(1):5-10.
Several pathophysiologic features of allergic inflammation, such as T(H) differentiation, the regulation of IgE, eosinophilia, mast cell proliferation, and cellular recruitment, are regulated by various cytokines. It has been of...
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Differential Expressions of IL-3 and FcepsilonRI in the Peripheral Blood Mononuclear Cells and Lesional Skin of Patients with Extrinsic Atopic Dermatitis and Intrinsic Atopic Dermatitis

Jin S, Noh S, Bae BG, Park CO, Lee KH

  • KMID: 1451617
  • Korean J Dermatol.
  • 2011 Jun;49(6):491-498.
BACKGROUND: A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed 'intrinsic' AD (IAD) as compared to its counterpart...
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Immune Characterization of Bone Marrow-Derived Models of Mucosal and Connective Tissue Mast Cells

Benedé S, Cody E, Agashe C, Berin MC

PURPOSE: It is well appreciated that mast cells (MCs) demonstrate tissue-specific imprinting, with different biochemical and functional properties between connective tissue MCs (CTMCs) and mucosal MCs (MMCs). Although in vitro...
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The Changes of Pro- and Anti-inflammatory Cytokines in Both Serum and Gastrocnemius Muscle of Mice after 2-hour Postischemic Reperfusion Injury

Kim SY

This study aimed to investigate the inflammatory changes and their main indicators according to the time-period of postischemic reperfusion injury confirmed by analyzing changes of both pro-inflammatory and anti-inflammatory cytokines...
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The Effect of Caffeine on 3T3-L1 Adipocyte Differentiation : A Nutrigenomical Approach

Kim MJ, Kim Y, Chung JH, Kim JW, Kim HK

  • KMID: 2257587
  • Korean J Nutr.
  • 2005 Oct;38(8):649-655.
Nutrigenomics refers to research that investigates the interaction between nutrition and the human genome. Caffeine in tea and coffee is widely and routinely consumed by people. This study was performed...
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Basophil Activation Test for Chronic Urticaria

Chirumbolo S

No abstract available.
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Two Cases of Atopic Dermatitis Treated with Thymopentin

Lee KY, Woo JH, Park CW, Lee CH

  • KMID: 1891549
  • Korean J Dermatol.
  • 1996 Aug;34(4):668-672.
The pat,hogenesis of atopic dermititis(AD) is still undefined. The prominent immunologic abnormalities associated with AD are defective cell-mediated immunity and increased IgE production. Also, the predominant CD4 subset in the...
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In Vitro Culture of Mast Cells from Human Umbilical Cord Blood Cells

Ahn KM, Lee SI

  • KMID: 1994352
  • Pediatr Allergy Respir Dis.
  • 1999 Dec;9(4):396-405.
PURPOSE: The purpose of this study is to induce the differentiation of mast cells from human umbilical cord blood. METHODS: Mononuclear cells and CD34+ cells were obtained from cord blood...
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In Vitro Effect of Interleukin-11 (IL-11) on Megakaryopoiesis from Umbilical Cord Blood Cells

Lee KK, Kim CK, Lee NS, Kim SJ, Cheong HJ, Lee KT, Park SK, Baick SH, Won JH, Hong DS, Park HS

BACKGROUND: The megakaryopoiesis and platelet production is regulated by several hematopoietc factors such as thrombopoietin (TPO), interleukin-11 (IL-11) and interleukin-3 (IL-3). IL-11 is a potent stimulator of megakaryopoiesis in vivo,...
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IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses

Kim S, Karasuyama H, Lopez AF, Ouyang W, Li X, Le Gros G, Min B

How Th2 immunity develops in vivo remains obscure. Basophils have been considered key innate cells producing IL-4, a cytokine essential for Th2 immunity. Increasing evidence suggests that basophils are dispensable...
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Analysis of stromal Cells Developed from Cord Blood CD34+ Cells

Ryu KH, Park SJ, Kim KH, Seoh JY, Khan M, Shin HY, Ahn HS

BACKGROUND: Cytokine-mediated ex vivo expansion has been proposed as a means of increasing the number of cord blood (CB) hematopoietic stem cells for transplantation. As well as stem cell number,...
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The Effects of Cyclosporin A and FK-506 on the Cytokine Production of Lymphocytes in Atopic Dermatitis

Park CW, Lee KY, Lee EH, Lee CH

BACKGROUND: It has been demonstrated that patients with atopic dermatitis(AD) show an impaired capacity of their T cells to release of interleukin-2(IL-2) in vitro and elevated serum levels of soluble...
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Expression of Cytokines in Nasal Polyps with Chronic Sinusitis and Asthma

Dhong HJ, Ha BS, Kim HY, Kim MS, Chung SK

  • KMID: 2276116
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Mar;47(3):227-231.
BACKGROUND AND OBJECTIVES: Rhinosinusitis has been closely related to asthma. However, the mechanistic roles of the cytokines in rhinosinusitis with asthma have not been well understood. We investigated the pattern...
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Studies of cocktail therapy with multiple cytokines for neoplasia or infectious disease of the dog I. cDNA cloning of canine IL-3 and IL-6

Shin IS, Kim HR, Nam MJ, Youn HY

  • KMID: 1103518
  • J Vet Sci.
  • 2001 Aug;2(2):115-120.
This paper describes the cloning and sequence analysis of the cDNAs encoding the canine homologues of interleukin-3 (IL-3) and interleukin-6 (IL-6). The coding sequences for canine IL-3 and IL-6 were...
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The Changes of Pro-inflammatory Cytokines in Serum according to the Reperfusion Time after Ischemia of Left Common Iliac Artery in Mice

Park KS, Kim SJ, Seo Y

Ischemia-reperfusion injury arises from the restoration of blood supply after ischemia. Both reactive oxygen species and various cytokines produced by activated immune cells are the primary causal risk factors for...
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Effect of cytokines and bFGF on the osteoclast differentiation induced by 1 alpha,25-(OH)2D3 in primary murine bone marrow cultures

Chae HJ, Kang JS, Bang BG, Cho SB, Han JI, Choi JY, Kim HM, Chae SW, Kim HR

  • KMID: 2071556
  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):539-546.
Bone is a complex tissue in which resorption and formation continue throughout life. The bone tissue contains various types of cells, of which the bone forming osteoblasts and bone resorbing osteoclasts are mainly...
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Effects of Korean Traditional Medicine on Murine Hematopoiesis (1) - Regulation of Hematopoietic Cytokine Expression -

Kim SH, Lim JS

  • KMID: 1550788
  • Korean J Immunol.
  • 1999 Jun;21(2):165-174.
The Korean traditional medicinal (KTM) herbs such as Angelicae gigantis, Rehmannia glutinosa, Paeoniae lactiflora, Cnidii officinale, Salviae miltiorrhizae, and Millettia reticulata, and prescribed formula Samultang, and Bohyultang improve the function...
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Antagonism of new Flavonoids from Sophorica japonica on IL-3-induced eosinophil activation

Kim MK, Kim YS

  • KMID: 2054867
  • J Asthma Allergy Clin Immunol.
  • 2000 Oct;20(5):725-730.
BACKGROUND: Even though allergic disease is an inflammatory disease, main inflammatory cells and cytokines involved in this process are different from those in other inflammatory diseases. New therapeutic targets on...
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The role of dependent pathway in eosinophil apoptosis

Ki SY, Jeon KW, Lee MR, Uh ST, Kim YH, Park CS, Chung IY

  • KMID: 2286031
  • J Asthma Allergy Clin Immunol.
  • 1999 Oct;19(5):667-684.
BACKGROUND: Interleukin-5 (IL-5), IL-3, and GM-CSF are known to prolong the survival of eosinophils, and IL-5 has the most potent effect on eosinophil survivaL It is also known that divergent signals induce...
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