Korean J Dermatol.  2011 Jun;49(6):491-498.

Differential Expressions of IL-3 and FcepsilonRI in the Peripheral Blood Mononuclear Cells and Lesional Skin of Patients with Extrinsic Atopic Dermatitis and Intrinsic Atopic Dermatitis

• Jin S
• Noh S
• Bae BG
• Park CO
• Lee KH

Abstract

BACKGROUND
A small subgroup of atopic dermatitis (AD) patients show low total and allergen-specific immunoglobulin (IgE) levels. This subgroup has been termed 'intrinsic' AD (IAD) as compared to its counterpart 'extrinsic' AD (EAD). However, the difference of cytokine expression between IAD and EAD has not been fully understood.
OBJECTIVE
To compare the expression of various inflammatory cytokines in the peripheral blood mononuclear cells (PBMCs) and lesional skin of patients with IAD and EAD, which are known to be associated with AD pathophysiology.
METHODS
We assessed the protein levels of cytokines in the PBMCs and lesional skin. We evaluated the levels of IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, FcepsilonRI and FcepsilonRII from the PBMCs and lesional skin of patients with IAD and EAD.
RESULTS
The patients with EAD had elevated levels of the IL-3 expression in their PBMCs and elevated levels of FcepsilonRI in their lesional skin compared to that of the patients with IAD. The expression of other cytokines did not differ in the PBMCs and lesional skin from the two subgroups.
CONCLUSION
This study suggests that IL-3 could be associated with the pathophysiology of EAD as compared to that of IAD, along with FcepsilonRI which was previously shown to be highly expressed in EAD patients.

Keyword

Atopic dermatitis; Extrinsic; FcepsilonRI; IL-3; Intrinsic

MeSH Terms

Cytokines
Dermatitis, Atopic
Humans
Immunoglobulins
Interleukin-10
Interleukin-13
Interleukin-3
Interleukin-4
Interleukin-5
Interleukin-6
Skin
Cytokines
Immunoglobulins
Interleukin-10
Interleukin-13
Interleukin-3
Interleukin-4
Interleukin-5
Interleukin-6