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Similar transplant outcomes between haploidentical and unrelated donors after reduced-intensity conditioning with busulfan, fludarabine, and anti-thymocyte globulin in patients with acute leukemia or myelodysplastic syndrome

Choi M, Heo JY, Shin DY, Lee JY, Koh Y, Hong J, Kim I, Yoon SS, Lee JO, Bang SM

BACKGROUND: Although T-cell-replete hematopoietic cell transplantation (HCT) from haploidentical donors (HIDs) using anti-thymocyte globulin (ATG) has shown promising outcomes, previous studies often adopted heterogenous graft sources and conditioning. METHODS: We retrospectively...
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Characteristics of DNMT3A mutations in acute myeloid leukemia

Park DJ, Kwon A, Cho BS, Kim HJ, Hwang KA, Kim M, Kim Y

BACKGROUND: DNMT3A mutations occur in approximately 20% of AML cases and are associated with changes in DNA methylation. CDKN2B plays an important role in the regulation of hematopoietic progenitor cells...
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A general view of CD33⁺ leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy

Fathi E, Farahzadi , Sheervalilou R, Sanaat Z, Vietor I

Acute myeloblastic leukemia (AML) is the most frequent acute leukemia in adulthood with very poor overall survival rates. In the past few decades, significant progresses had led to the findings...
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Bibliometric analysis of studies about acute myeloid leukemia conducted globally from 1999 to 2018

Seo B, Kim J, Kim S, Lee E

A bibliometric study is performed to analyze publication patterns in a specific research area and to establish a landscape model that can be used to quantitatively weigh publications. This study...
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Pretransplant Hepatic Malignancy Increases Risk of De Novo Malignancy after Liver Transplantation

Park GC, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Yoon YI, Cho HD, Kwon JH, Chung YK, Kang SH, Choi JU, Jung IJ, Lee SG

BACKGROUND: Hepatocellular carcinoma (HCC) recurrence and development of de novo malignancy (DNM) after liver transplantation (LT) are the major causes of late recipient death. METHODS: We analyzed the incidence of extrahepatic...
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Acute Leukemia Relapse Presenting as Recurrent Involvement of the Optic Nerve

Lee SY, Yoon JH, Chung SA

PURPOSE: To report two cases with recurrent involvement of the optic nerve as the initial sign of acute leukemic relapse. CASE SUMMARY: An 8-year-old male with acute lymphoblastic leukemia on the...
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Acute Lymphoblastic Leukemia in a Patient Treated with Letrozole and Palbociclib

Park JH, Park H, Kim KH, Kim JS, Choi IS, Roh EY, Kim JE, Chang MS

Palbociclib, in conjunction with endocrine therapy, has been approved for the treatment of patients with advanced breast cancer. The common hematological toxicities associated with palbociclib are leukopenia and neutropenia. However,...
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A Case of Acute Lymphoblastic Leukemia Presenting as Unilateral Sternoclavicular Joint Arthritis and Mass

Park EJ, Hyun CL, Kim J

No abstract available.
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A Case of Donor Cell Leukemia after Allogenic Peripheral Blood Stem Cell Transplantation for Acute Promyelocytic Leukemia with PML-RARA

Shin WY, Bang HI, Kim J, Kim KH, Won JH, Park R

Donor cell leukemia (DCL), a rare but fatal complication arising from allogenic stem cell transplantation, is a complex disease associated with multiple pathophysiological processes. Specific diagnosis of DCL distinct from...
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First Case of Double T-Cell Receptor Alpha/Delta Rearrangements of t(11;14) and inv(14) and Subsequent JAK2 Rearrangement in a Patient With T-cell Acute Lymphoblastic Leukemia

Seol CA, Cho YU, Jang S, Park CJ, Lee JH, Seo EJ

No abstract available.
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Performance Evaluation of the QXDx BCR-ABL %IS Droplet Digital PCR Assay

Chung HJ, Hur M, Yoon S, Hwang K, Lim HS, Kim H, Moon HW, Yun YM

Accurate detection of BCR-ABL fusion transcripts at and below molecular response (MR) 4 (0.01% International Scale [IS]) is required for disease monitoring in patients with chronic myeloid leukemia (CML). We...
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JL1 Antigen Expression on Bone Marrow Lymphoma Cells from Patients With Non-Hodgkin Lymphoma

Kim MS, Park CJ, Cho YU, Jang S, Seo EJ, Park CS, Huh J, Im HJ, Seo JJ, Yoon DH, Suh C

BACKGROUND: JL1, a CD43 epitope and mucin family cell surface glycoprotein, is expressed on leukemic cells. An anti-JL1 antibody combined with a toxic substance can have targeted therapeutic effects against...
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Posaconazole versus Itraconazole as Prophylactic Antifungal Agents during Induction Chemotherapy for Acute Myeloid Leukemia: A Real-World Single Center Comparison

Kim C, Yoon SY, Lee MY, Kim KH, Lee N, Won JH

OBJECTIVE: To prevent invasive fungal disease (IFD) in acute myeloid leukemia (AML) patients, the use of posaconazole as a prophylactic antifungal agent has become standard in patients undergoing induction chemotherapy....
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Anti-tumor activity and mitochondrial stability of disulfiram in HL-60 cells

Disulfiram (DSF) is a member of the dithiocarbamate family that can bind copper. Recent studies have shown that DSF has anti-cancer activities, but the mechanism has not been clarified. Therefore,...
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Leukostasis by hyperleukocytic childhood acute leukemia: pathophysiology, clinical presentation, and emergency care

Nam KL, Baek GY, Jeon IS

Hyperleukocytosis (HL), defined by a peripheral white blood cell (WBC) count exceeding 100,000/mm³, is occasionally observed in childhood acute leukemia. The increased viscosity in the micro-circulation by HL and the...
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Transfusional Iron Overload and Choroid Plexus Hemosiderosis in a Pediatric Patient: Brain Magnetic Resonance Imaging Findings

Kim MS, Lee HY, Lim MK, Kang YH, Kim JH, Lee KH

Hemosiderosis is characterized by the deposition of excess iron in body tissues. The choroid plexus is an important part of the central nervous system that can be the primary site...
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Treatment of Adult Spinal Deformity with Sagittal Imbalance Using Oblique Lumbar Interbody Fusion: Can We Predict How Much Lordosis Correction Is Possible?

Kim WJ, Lee JW, Park KY, Chang SH, Song DG, Choy WS

STUDY DESIGN: Prospective, single-center study. PURPOSE: The current trend of operative treatment for adult spinal deformity (ASD) is combined anterior-posterior staged surgery. When anterior surgery was first performed, oblique lumbar interbody...
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Differential impact of anti-thymocyte globulin dosing by disease risk index in alternative donor peripheral blood stem cell transplantation in patients with acute leukemia or myelodysplastic syndrome after reduced intensity conditioning

Choi M, Shin DY, Lee JY, Kim I, Yoon SS, Bang SM

No abstract available.
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Long-term response in refractory AML following azacitidine-failed MDS by salvage decitabine-bridged allogenic transplantation

Niscola P, Grazia CD, Mazzone C, Tolu B, de Fabritiis P, Angelucci

No abstract available.
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Chronic lymphocytic leukemia with unusual cytoplasmic anomalies

Athanase N

No abstract available.
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