Ann Dermatol.  2003 Jun;15(2):64-67. 10.5021/ad.2003.15.2.64.

A Case of Leukemia Cutis in Myelodysplastic Syndrome Evolving into An Atypical Chronic Myeloid Leukemia

• Ryu HJ
• Kye YC
• Kim SN

• KMID: 2158684
• DOI: http://doi.org/10.5021/ad.2003.15.2.64

Abstract

We report a patient who had been initially diagnosed as a myelodysplastic syndrome in 1998 presenting purpuric patches on the left arm that started to develop about a year prior. The purpuric lesions were diagnosed as leukemia cutis by skin biopsy. Her subsequent bone marrow biopsy showed progression into an atypical chronic myeloid leukemia with increased numbers of leukocytes in the peripheral blood. Leukemia cutis typically is regarded as a sign of progression of disease or a manifestation of recurrent disease in treated patients with an established diagnosis of leukemia. We suggest that the skin lesion in this patient could have been a sign of con-version into atypical chronic myeloid leukemia.

Keyword

Leukemia cutis; Atypical chronic myeloid leukemia; Myelodysplastic syndrome.

MeSH Terms

Arm
Biopsy
Bone Marrow
Diagnosis
Humans
Leukemia*
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative*
Leukocytes
Myelodysplastic Syndromes*
Skin