Clin Pediatr Hematol Oncol.
2022 Oct;29(2):89-91. 10.15264/cpho.2022.29.2.89.
A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis
- Affiliations
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- 1Departments of Pediatrics, Chungnam National University Hospital, Daejeon, Korea
- 2Departments of Laboratory Medicine, Chungnam National University Hospital, Daejeon, Korea
- KMID: 2534770
- DOI: http://doi.org/10.15264/cpho.2022.29.2.89
Abstract
- B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common type of ALL, has an excellent prognosis with long-term event-free survival of 90%. The malignancy has several genetic abnormalities that may influence patient prognosis. Rearrangements of the three immunoglobulin genes IGK (2p12), IGH (14q32), and IGL (22q11) are often seen, especially in non-Hodgkin lymphoma (NHL), but recombination of these genes are uncommon. The translocation, t(14;22)(q32;q11) has been reported in only 9 B-cell leukemia/lymphoma cases, but there has been no report about the clinical feature and prognosis of BCP-ALL with t(14;22)(q32;q11). In this paper, we describe the first pediatric case of BCP-ALL with t(14;22)(q32;q11) who presented with a very high white blood cell (WBC) count. He achieved cytogenetic complete remission after induction chemotherapy, and negative minimal residual disease (MRD) at the end of consolidation.
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