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Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin

Espósito , Brianezi G, de Souza N, Miot LD, Miot HA

BACKGROUND: Melasma is a chronic acquired focal hypermelanosis which pathogenesis has not been fully elucidated. Classical pathophysiologic studies have analysed the affected and perilesional areas, but little is known about...
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Rare Cases of PLOD1-Related Kyphoscoliotic Ehlers-Danlos Syndrome in a Korean Family Identified by Next Generation Sequencing

Shin YL, Park YN, Jang MA

Kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is an autosomal recessive connective tissue disorder characterized by muscular hypotonia, hyperextensible skin, skin fragility, joint hypermobility, and progressive kyphoscoliosis. The disorder results from a deficiency...
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Proteomic Classification and Identification of Proteins Related to Tissue Healing of Platelet-Rich Plasma

Lee HW, Choi KH, Kim JY, Kim KO, Haotian B, Yuxuan L, Noh KC

BACKGROUND: Platelet-rich plasma (PRP) is a plasma component of autologous blood containing a high concentration of platelets. PRP is used to promote healing of damaged tissues. However, there are not...
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Paget's Disease of Bone Affecting Peripheral Limb: Difficulties in Diagnosis: A Case Report

Lee JK, Kang YK, Wang PW, Hong SM

In terms of management of Paget's disease of bone (PDB), early diagnosis and proper management achieving remission is essential with lifelong specialist follow-up. We present the case of a 40-year-old...
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Reference Intervals for Bone Turnover Markers in Korean Healthy Women

Cho DH, Chung JO, Chung MY, Cho JR, Chung DJ

BACKGROUND: Adequate suppression of bone turnover rate is important to decrease fracture risk without mineralization defect due to oversuppression. This study was performed to determine reference intervals (RIs) for 2...
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Prognostic value of COL6A3 in pancreatic adenocarcinoma

Svoronos C, Tsoulfas G, Souvatzi M, Chatzitheoklitos E

BACKGROUNDS/AIMS: Pancreatic cancer is one of the most fatal human malignancies with poor prognosis, despite advances in therapy. Here, we evaluated the potential role of collagen type VI α3 chain...
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Dietary nobiletin suppresses TGF-β1-Src-caveolin-1 dependent signaling involved with high glucose-induced renal mesangial matrix accumulation

Kim DY, Kang YH, Kang MK

PURPOSE: Diabetic nephropathy is one of the most important diabetic complications prompted by chronic hyperglycemia, characterized by glomerulosclerosis, tubular fibrosis, and it eventually causes kidney failure. Nobiletin is a polymethoxyflavone...
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Distinctive bone regeneration of calvarial defects using biphasic calcium phosphate supplemented ultraviolet-crosslinked collagen membrane

Hong I, Khalid AW, Pae HC, Cha JK, Lee JS, Paik JW, Jung UW, Choi SH

PURPOSE: To overcome several drawbacks of chemically-crosslinked collagen membranes, modification processes such as ultraviolet (UV) crosslinking and the addition of biphasic calcium phosphate (BCP) to collagen membranes have been introduced....
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Corneal Collagen Cross-linking for Corneal Ulcer from Moraxella Group

Woo SE, Lee SH

PURPOSE: To report a case of corneal collagen cross-linking for corneal ulcer caused by the Moraxella group. CASE SUMMARY: A 77-year-old male had decreased visual acuity for several days in his...
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Bioactivity of endodontic biomaterials on dental pulp stem cells through dentin

Javid B, Panahandeh N, Torabzadeh H, Nazarian H, Parhizkar , Asgary S

OBJECTIVES: This study investigated the indirect effect of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA), as 2 calcium silicate-based hydraulic cements, on human dental pulp stem cells (hDPSCs)...
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The effect of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion

Hwang S, Chung CJ, Choi YJ, Kim T, Kim KH

OBJECTIVE: The objective of this study was to evaluate the effects of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion. METHODS: Sixty male Sprague–Dawley rats were...
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Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons

Kang YM, Lee SK, Chun YM, Choi YR, Moon SH, Lee HM, Kang HJ

PURPOSE: The aim of this study was to investigate the effect of FST gene on the inhibition of fibrosis in fibroblastic cells from scar tissue around repaired zone II flexor...
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Horizontal ridge augmentation using guided bone regeneration technique in two young patients with localized alveolar ridge defect: A case report

Kim DH, Jeong SN

Lateral ridge augmentation using guided bone regeneration technique is a frequently performed procedure that is used for restoring localized bone defects after extraction. In particular, demineralized bovine bone material and...
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Bone and tissue reaction of porous nickel-titanium alloy implant for dental implants in rabbits

Min GH, Lee KH, Sung SJ, Lee WP, Yu SJ, Kim BO

Porous nickel–titanium (Ni-Ti) alloy implants have been previously introduced, and many studies have been performed. Porous Ni-Ti alloys have excellent properties for use in the dental field. Thus, the use...
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Guided bone regeneration in peri-implant defects using a 1:1 mixture of cancellous and cortical freeze-dried bone allograft: A randomized controlled trial

Lee WP, Park DY, Lee KW, Yang KI, Kim BO, Yu SJ

The results of guided bone regeneration (GBR) in peri-implant defects using anorganic bovine bone (ABB) were compared with those using a 1:1 mixture of cancellous and cortical freeze-dried bone allograft...
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A Case of Surgical Treatment of Intractable Vocal Fold Scar Using Basic Fibroblast Growth Factor and Collagen Scaffold

Kang HT, Kim HJ, Park KN, Lee SW

Vocal fold scarring is an intractable phonosurgical condition. The number of patients with vocal fold scars is increasing with the aging of society and with the increasing application of laryngeal...
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Coincidence of Dermal Melanocyte Hamartoma and Becker's Nevus in a Patient with Neurofibromatosis Type 1

Kim YJ, Choi ME, Lee MW, Choi JH, Chang SE

  • KMID: 2470219
  • Korean J Dermatol.
  • 2019 Dec;57(10):632-634.
Dermal melanocytosis is characterized by an increased number of ovoid to elongated melanocytes situated between collagen fibers in the dermis, including blue nevus, Mongolian spots, nevus of Ota and Ito...
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Acquired Periungual Fibrokeratoma: An Atypical Case Covering the Entire Thumb Nail

Ryu JY, Park CJ, Lee KH

  • KMID: 2470215
  • Korean J Dermatol.
  • 2019 Dec;57(10):617-620.
Acquired periungual fibrokeratoma, first reported by Cahn in 1977, is a rare, benign fibrous tissue tumor located in the periungual area. The pathophysiology of acquired periungual fibrokeratoma is unknown. In...
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Skeletal mineralization: mechanisms and diseases

Michigami

Skeletal mineralization is initiated in matrix vesicles (MVs), the small extracellular vesicles derived from osteoblasts and chondrocytes. Calcium and inorganic phosphate (Pi) taken up by MVs form hydroxyapatite crystals, which...
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Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies

Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S

STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against...
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