J Korean Assoc Oral Maxillofac Surg.  2012 Dec;38(6):321-325. 10.5125/jkaoms.2012.38.6.321.

Collagen biology for bone regenerative surgery

• Murata M

• KMID: 2136967
• DOI: http://doi.org/10.5125/jkaoms.2012.38.6.321

Abstract

Collagen is widely used for regenerative therapy and pharmaceutical applications as one of the most useful scaffolds. Collagen is the most abundant protein in vertebrates and the natural substrate of various types of animal cells. Bone and dentin are mineralized tissues and almost similar in chemical components. They consist of collagen (18%), non-collagenous proteins (2%), hydroxyapatite (70%) and body fluid (10%) in weight volume. Pepsin-digested, type I collagen (atelocollagen) and heat-denatured collagen (gelatin) are basic collagenous materials for medical use. Demineralized dentin matrix (DDM) and demineralized bone matrix (DBM) belong to acid-insoluble group, and vital tooth-derived DDM is a unique dentin material including cementum and growth factors. In this review, collagen-based materials will be introduced and discussed for bone regenerative surgery.

Keyword

Collagen; Biomaterial; Dentin; Bone; Regeneration

MeSH Terms

Animals
Biology
Body Fluids
Bone Matrix
Collagen
Collagen Type I
Dental Cementum
Dentin
Durapatite
Intercellular Signaling Peptides and Proteins
Proteins
Regeneration
Vertebrates
Collagen
Collagen Type I
Dentin
Durapatite
Intercellular Signaling Peptides and Proteins
Proteins

Figure

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  Fig. 1 Diagram of common components in dentin and bone. (HAP: hydroxyapatite, OCN: osteocalcin, BMP: bone morphogenetic protein, FGFs: fibroblast growth factors)

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  Fig. 2 Preparation method for collagenous materials. Atelocollagen: acid-soluble matrix, DDM and DBM: acid-insoluble matrix. (DDM: demineralized dentin matrix, DBM: demineralized bone matrix)

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  Fig. 3 SEM of collagenous materials. A. Atelocollagen fibers. B. Plate-like gelatin. C. DBM particle. D. DDM particle. (DBM: demineralized bone matrix, DDM: demineralized dentin matrix)

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