- Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases
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Kang MJ
- KMID: 2471886
- Tuberc Respir Dis.
- 2020 Apr;83(2):107-115.
- doi: 10.4046/trd.2020.0003
Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying... -
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- New Insights on the Mechanisms Affecting Fertility in Men with Non-Seminoma Testicular Cancer before Cancer Therapy
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Dias TR, Agarwal A, Pushparaj , Ahmad G, Sharma R
- KMID: 2471826
- World J Mens Health.
- 2020 Apr;38(2):198-207.
- doi: 10.5534/wjmh.180099
PURPOSE: Patients with non-seminoma testicular cancer (NSTC) cancer can be subfertile or infertile, and present reduced sperm quality, but the underlying mechanisms are unknown. The aim of this study was... -
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- Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis
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Yin H, Wang S, Gu C
- KMID: 2471339
- Ann Dermatol.
- 2020 Apr;32(2):130-140.
- doi: 10.5021/ad.2020.32.2.130
BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,... -
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- Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors
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Park J, Yoo HM, Sul HJ, Shin S, Lee SW, Kim JG
- KMID: 2471923
- J Gastric Cancer.
- 2020 Mar;20(1):29-40.
- doi: 10.5230/jgc.2020.20.e2
PURPOSE: Gastrointestinal stromal tumors (GISTs) frequently harbor activating gene mutations in either KIT or platelet-derived growth factor receptor A (PDGFRA) and are highly responsive to several selective tyrosine kinase inhibitors.... -
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- 2019 Novel Coronavirus Disease Outbreak and Molecular Genetic Characteristics of Severe Acute Respiratory Syndrome-Coronavirus-2
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Jeong YS
- KMID: 2471832
- J Bacteriol Virol.
- 2020 Mar;50(1):1-8.
- doi: 10.4167/jbv.2020.50.1.001
The 2019 novel coronavirus disease (COVID-19) outbreaks that emerged in Wuhan city, Hubei province, have led to a formidable number of confirmed cases that resulted in >5,700 deaths globally, including... -
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- Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model
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Khalmuratova R, Lee M, Park JW, Shin HW
- KMID: 2468464
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):306-321.
- doi: 10.4168/aair.2020.12.2.306
PURPOSE: Osteitis refers to the development of new bone formation and remodeling of bone in chronic rhinosinusitis (CRS) patients; it is typically associated with eosinophilia, nasal polyps (NPs), and recalcitrant... -
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- Review of a novel disease entity, immunoglobulin G4-related disease
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Maehara T, Moriyama M, Nakamura S
- KMID: 2471106
- J Korean Assoc Oral Maxillofac Surg.
- 2020 Feb;46(1):3-11.
- doi: 10.5125/jkaoms.2020.46.1.3
Immunoglobulin G4 (IgG4)-related dacryoadenitis and sialoadenitis (IgG4-DS) are part of a multiorgan fibroinflammatory condition of unknown etiology termed IgG4-related disease (IgG4-RD), which has been recognized as a single diagnostic entity... -
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- Reverse vaccinology approach for the identification and characterization of outer membrane proteins of Shigella flexneri as potential cellular- and antibody-dependent vaccine candidates
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Leow CY, Kazi A, Hisyam Ismail CMK, Chuah C, Lim BH, Leow CH, Banga Singh KK
- KMID: 2470834
- Clin Exp Vaccine Res.
- 2020 Jan;9(1):15-25.
- doi: 10.7774/cevr.2020.9.1.15
PURPOSE: In the developing world, bacillary dysentery is one of the most common communicable diarrheal infections. There are approximately 169 million cases of shigellosis reported worldwide. The disease is transmitted... -
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- Autophagy in neutrophils
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Shrestha S, Lee JM, Hong CW
- KMID: 2466564
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):1-10.
- doi: 10.4196/kjpp.2020.24.1.1
Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy... -
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- Comprehensive Molecular Characterization of Urological Malignancies: Literature Review of Landmark Studies
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Suh J, Jeong CW
- KMID: 2470397
- Korean J Urol Oncol.
- 2019 Dec;17(3):125-135.
- doi: 10.22465/kjuo.2019.17.3.125
Owing to recent advancements in next-generation sequencing and bioinformatics, genetic data of urological malignancies exponentially studied and published. Application of precision medicine strategies for cancer diagnosis, management is just around... -
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- TarGo: network based target gene selection system for human disease related mouse models
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Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK
- KMID: 2470013
- Lab Anim Res.
- 2019 Dec;35(4):165-171.
- doi: 10.1186/s42826-019-0023-z
Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are... -
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- Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis
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Kang JM, Yoo WG, Lê HG, Thái TL, Hong SJ, Sohn WM, Na BK
- KMID: 2470001
- Korean J Parasitol.
- 2019 Dec;57(6):671-680.
- doi: 10.3347/kjp.2019.57.6.671
Cathepsin D (CatD, EC 3.4.23.5) is a member belonging to the subfamily of aspartic endopeptidases, which are classified into the MEROPS clan AA, family A1. Helminth parasites express a large... -
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- AI, big data, and robots for the evolution of biotechnology
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Kim H
- KMID: 2468870
- Genomics Inform.
- 2019 Dec;17(4):e44.
- doi: 10.5808/GI.2019.17.4.e44
Artificial intelligence (AI), big data, and ubiquitous robotic companions —the three most notable technologies of the 4th Industrial Revolution—are receiving renewed attention each day. Technologies that can be experienced in... -
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- Propionic Acidemia with Novel Mutation Presenting as Recurrent Pancreatitis in a Child
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Choe JY, Jang KM, Min SY, Hwang SK, Kang B, Choe BH
- KMID: 2465006
- J Korean Med Sci.
- 2019 Dec;34(47):e303.
- doi: 10.3346/jkms.2019.34.e303
Propionic acidemia (PA) is a rare organic acidemia resulting from a deficiency of the mitochondrial enzyme propionyl-coenzyme A carboxylase. Most cases are diagnosed after the detection of metabolic abnormalities—such as... -
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- A Novel RUNX2 Mutation in a Korean Family with Cleidocranial Dysplasia
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Lee JW, Song J, Shin TJ, Hyun HK, Kim YJ, Lee SH, Kim J, Kim JW
- KMID: 2467077
- J Korean Acad Pediatr Dent.
- 2019 Nov;46(4):409-415.
- doi: 10.5933/JKAPD.2019.46.4.409
Cleidocranial dysplasia (CCD) is an autosomal-dominant disease characterized by the delayed closure of cranial sutures, defects in clavicle formation, supernumerary teeth, and delayed tooth eruption. Defects in the Runt-related transcription... -
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- Molecular and Clinicopathological Features of Gastrointestinal Stromal Tumors in Vietnamese Patients
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Ngo QD, Pham QT, Phan DA, Hoang AV, Hua TN, Nguyen ST
- KMID: 2465435
- J Pathol Transl Med.
- 2019 Nov;53(6):361-368.
- doi: 10.4132/jptm.2019.08.27
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. Management of GIST patients is currently based on clinicopathological features and associated genetic changes. However,... -
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- Long term recurrence free survival in a stage IV gallbladder cancer treated with chemotherapy plus trastuzumab and salvage liver resection
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Prieto M, Gastaca M, Ruiz P, Ventoso A, Palomares , Perfecto A, Valdivieso A
- KMID: 2464332
- Ann Hepatobiliary Pancreat Surg.
- 2019 Nov;23(4):403-407.
- doi: 10.14701/ahbps.2019.23.4.403
Surgery is the only treatment for biliary tract cancer with long term survival. Unfortunately, most patients are diagnosed at stage IV with distant metastases. In these circumstances, life expectancy is... -
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- Role of Helix 8 in Dopamine Receptor Signaling
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Yang HS, Sun N, Zhao X, Kim HR, Park HJ, Kim KM, Chung KY
- KMID: 2462878
- Biomol Ther.
- 2019 Nov;27(6):514-521.
- doi: 10.4062/biomolther.2019.026
G protein-coupled receptors (GPCRs) are membrane receptors whose agonist-induced dynamic conformational changes trigger heterotrimeric G protein activation, followed by GRK-mediated phosphorylation and arrestin-mediated desensitization. Cytosolic regions of GPCRs have been... -
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- Molecular Genetics of von Willebrand Disease in Korean Patients: Novel Variants and Limited Diagnostic Utility of Multiplex Ligation-Dependent Probe Amplification Analyses
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Kim HJ, Kim SK, Yoo KY, Lee KO, Yun JW, Kim SH, Kim HJ, Park SK
- KMID: 2450949
- Ann Lab Med.
- 2019 Nov;39(6):545-551.
- doi: 10.3343/alm.2019.39.6.545
BACKGROUND: von Willebrand disease (VWD), characterized by quantitative or qualitative defects of von Willebrand factor (VWF), is the most common inheritable bleeding disorder. Data regarding the genetic background of VWD... -
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- Comparison of responsiveness to cancer development and anti-cancer drug in three different C57BL/6N stocks
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Kang MJ, Kim JE, Park JW, Choi HJ, Bae SJ, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK
- KMID: 2470007
- Lab Anim Res.
- 2019 Oct;35(3):114-123.
- doi: 10.1186/s42826-019-0015-z
In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies.... -
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