Ann Lab Med.  2012 Jul;32(4):289-293. 10.3343/alm.2012.32.4.289.

MYC Rearrangement Involving a Novel Non-immunoglobulin Chromosomal Locus in Precursor B-cell Acute Lymphoblastic Leukemia

• Seo JY
• Lee SH
• Kim HJ
• Yoo KH
• Koo HH
• Cho YG
• Choi SI
• Kim SH

• KMID: 1380089
• DOI: http://doi.org/10.3343/alm.2012.32.4.289

Abstract

MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia.

Keyword

Precursor B-cell acute lymphoblastic leukemia; MYC gene rearrangement; Non-immunoglobulin partner

MeSH Terms

Bone Marrow Cells/pathology
Child, Preschool
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 8
Genetic Loci
Humans
Immunoglobulins/genetics
Karyotyping
Male
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics/metabolism/pathology
Proto-Oncogene Proteins c-myc/*genetics
Recurrence
Translocation, Genetic

Figure

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  Fig. 1 Morphology of the leukemic blasts in the cerebrospinal fluid at first relapse (A) and in the bone marrow at second relapse (B) (Wright-Giemsa stain, ×1,000).

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  Fig. 2 Cytogenetic analysis showing complex chromosomal abnormalities including t(4;8)( q31.1;q24.1). Black arrows indicate the rearranged chromosomes 4 and 8 (A). FISH analysis using the Vysis LSI MYC Dual Color, Break Apart Rearrangement Probe (Abbott Molecular Inc.), which showed the MYC gene rearrangement. White arrow indicates a interphase cell with 1 fusion and 1 break apart signal (B).

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