Korean J Lab Med.  2009 Jun;29(3):199-203. 10.3343/kjlm.2009.29.3.199.

A Novel Translocation t(1;5)(p32;q31) that Was Not Associated with the TAL1 Rearrangement in a Case of T Lymphoblastic Leukemia/Lymphoma

• Cho HS
• Kim MK
• Bae YK

• KMID: 1096970
• DOI: http://doi.org/10.3343/kjlm.2009.29.3.199

Abstract

Chromosome 1 band p32 (1p32) aberrations are common in T lymphoblastic leukemia/lymphoma (T-ALL/LBL). Two types of 1p32 aberrations include translocations with different partners and submicroscopic interstitial deletion. Both aberrations are known to result in TAL1 gene deregulation. The t(1;5)(p32;q31) is a rare translocation of 1p32 in T-ALL. We now present the second case of t(1;5)(p32;q31) in T-ALL, which was present as a primary cytogenetic abnormality, with a review of the relevant literature. Interestingly, neither the translocation of the TAL1 gene nor aberrant expression of TAL1 protein was detected by fluorescent in situ hybridization (FISH) and by immunohistochemical staining in this case.

Keyword

T-ALL; t(1;5)(p32;q31); TAL1 gene

MeSH Terms

Basic Helix-Loop-Helix Transcription Factors/*genetics/metabolism
Bone Marrow/pathology
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 5
Humans
Karyotyping
Male
Middle Aged
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics/pathology
Proto-Oncogene Proteins/*genetics/metabolism
Tomography, X-Ray Computed
*Translocation, Genetic

Figure

• 

  Fig. 1. (A) The bone marrow aspirates (Wright stain, ×1,000) and (B) biopsy (hematoxylin and eosin stain, ×200) showed an increase of small to medium sized blasts.

• 

  Fig. 2. The representative karyotype showed 46,XY,t(1;5) (p32;q31). Translocation chromosomes are indicated by arrows (GTG banding, ×1,000).

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  Fig. 3. The TAL1 gene translocation or submicroscopic deletion was not detected by FISH (×1,000).

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  Fig. 4. Immunohistochemical stainings for TAL1 were negative. (A) 2TL242 on bone marrow, (B) BTL73 on bone marrow, (C) 2TL242 on lymph node, (D) BTL73 on lymph node (×400).

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