J Korean Med Assoc.  2006 Aug;49(8):717-730. 10.5124/jkma.2006.49.8.717.

Pathogenesis of Alzheimer's Dementia

• Suh YH

• KMID: 2184701
• DOI: http://doi.org/10.5124/jkma.2006.49.8.717

Abstract

Alzhelmer's disease (AD) is the most common cause of dementia that arises on a neuropathological background of amyloid plaques containing betaamylold (Abeta) derived from amyloid precursor protein (APP) and tau-rich neurofibrillary tangles. To date, the cause and progression of familial or sporadic AD have not been fully elucidated. About 10% of all cases of AD occur as autosomal dominant inherited forms of early-onset AD, which are caused by mutations in the genes encoding APP, presenilin-1 and presenilin-2. Proteolytic processing of APP by beta-gamma-secretase and caspase generates Abetaand carboxyl-terminal fragments of APP (APP-CTFs), which have been implicated in the pathogenesis of AD. The presenilins function as one of the gamma-secretases. Abetawhich is the main component of the amyloid plaques found, is known to exert neurotoxicity by accumulating free radicals, disturbing calcium homeostasis, evoking inflammatory response and activating signaling pathways. The CTFs have been found in AD patients' brain and reported to exhibit much greater neurotoxicity than Abeta. Furthermore CTFs are known to impair calcium homeostasis and learning and memory, triggering a strong inflammatory reaction through MAPKs- and NF-kappaB-dependent astrocytosis and iNOS induction. Recently, it was reported that CTF translocated into the nucleus and in turn, affected transcription of genes including glycogen synthase kinase-3beta which results in the induction of tau-rich neurofibrillary tangles and subsequently cell death. One of the hallmarks of AD, neurofibrillary tangles (NFT), is formed by insoluble intracellular polymers of hyperphosphorylated tau that is believed to cause apoptosis by disrupting cytoskeletal and axonal transport. This review covers the processing of APP, toxic mechanisms of Abetaand CTFs of APP, presenilin and also tau in relation to the pathogenesis of AD.

Keyword

Pathogenesis; AD

MeSH Terms

Amyloid
Apoptosis
Axonal Transport
Brain
Calcium
Cell Death
Dementia*
Free Radicals
Gliosis
Glycogen Synthase
Homeostasis
Learning
Memory
Neurofibrillary Tangles
Plaque, Amyloid
Polymers
Presenilin-1
Presenilin-2
Presenilins
Amyloid
Calcium
Free Radicals
Glycogen Synthase
Polymers
Presenilin-1
Presenilin-2
Presenilins

Figure

• 

  Figure 1 Structure and processing of APP

• 

  Figure 2 Hypothesis of an etiological role of amyloidogenic CTF of APP in AD

• 

  Figure 3 The tau and tangle hypothesis

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