- Clinical Aspects of Genetic Testing for Dementia
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Lee SH, Park KW
- KMID: 2338710
- J Korean Geriatr Soc.
- 2008 Mar;12(1):5-10.
Dementia is the progressive or chronic dysfunction of cortical or subcortical functions that results in complex cognitive decline and Alzheimer's disease is the most common etiology of dementia. Currently, causal... -
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- Alzheimer's Disease and Apoptosis
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Kim YH, Kim YK, Kim SH, Lee SK, Kim SS, Kim HS, Park CH, Jeong SJ, Suh YH
- KMID: 1834623
- J Korean Soc Biol Psychiatry.
- 1998 Jun;5(1):66-70.
Apoptosis is a form of cell death in which the cells shrink and exhibit nuclear chromatin condensation and DNA fragmentation, and yet maintain membrane integrity. Many lines of evidence have... -
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- Pathogenesis of Alzheimer's Dementia
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Suh YH
- KMID: 2184701
- J Korean Med Assoc.
- 2006 Aug;49(8):717-730.
- doi: 10.5124/jkma.2006.49.8.717
Alzhelmer's disease (AD) is the most common cause of dementia that arises on a neuropathological background of amyloid plaques containing betaamylold (Abeta) derived from amyloid precursor protein (APP) and tau-rich... -
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- Identification of PSEN1 and APP Gene Mutations in Korean Patients with Early-Onset Alzheimer's Disease
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Park HK, Na DL, Lee JH, Kim JW, Ki CS
- KMID: 1713451
- J Korean Med Sci.
- 2008 Apr;23(2):213-217.
- doi: 10.3346/jkms.2008.23.2.213
Although mutations in three genes, amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2), have been identified as genetic causes of earlyonset Alzheimer s disease (EOAD), there has... -
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- Contributing Factors to Diabetic Brain Injury and Cognitive Decline
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Verma N, Despa F
- KMID: 2460949
- Diabetes Metab J.
- 2019 Oct;43(5):560-567.
- doi: 10.4093/dmj.2019.0153
The link of diabetes with co-occurring disorders in the brain involves complex and multifactorial pathways. Genetically engineered rodents that express familial Alzheimer's disease-associated mutant forms of amyloid precursor protein and... -
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- Nicotinamide Reduces Amyloid Precursor Protein and Presenilin 1 in Brain Tissues of Amyloid Beta-Tail Vein Injected Mice
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Kim EJ, Yang SJ
- KMID: 2383701
- Clin Nutr Res.
- 2017 Apr;6(2):130-135.
- doi: 10.7762/cnr.2017.6.2.130
The purpose of this study is to investigate whether nicotinic acid (NA) and nicotinamide (NAM) reduce the Alzheimer disease (AD)-related gene expression in brain tissues of amyloid beta (Aβ)-injected mice.... -
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- Molecular Genetics of Primary Intracerebral Hemorrhage
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Ahn JY, Kim JK, Chung YS, Chung SS, Joo JY
- KMID: 1579197
- Korean J Cerebrovasc Surg.
- 2004 Mar;6(1):5-10.
Intracerebral hemorrhage (ICH) is more deadly than ischemic stroke but is also rarer and more difficult to study. Genetic and environmental risk factors likely play a role in the occurrence... -
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- PSEN1 p.Met233Val in a Complex Neurodegenerative Movement and Neuropsychiatric Disorder
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Appel-Cresswell S, Guella I, Lehman A, Foti D, Farrer MJ
- KMID: 2405202
- J Mov Disord.
- 2018 Jan;11(1):45-48.
- doi: 10.14802/jmd.17066
Mutations in presenilin 1 (PSEN1) are the most common cause of autosomal dominant Alzheimer's disease. Here, we report a Canadian-Vietnamese family carrying a PSEN1 p.Met233Val mutation with an exceptionally early... -
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- iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia
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Li L, Roh JH, Chang EH, Lee Y, Lee S, Kim M, Koh W, Chang JW, Kim HJ, Nakanishi , Barker RA, Na DL, Song J
- KMID: 2424730
- Exp Neurobiol.
- 2018 Oct;27(5):350-364.
- doi: 10.5607/en.2018.27.5.350
Disease modeling of Alzheimer's disease (AD) has been hampered by the lack of suitable cellular models while animal models are mainly based on the overexpression of AD-related genes which often... -
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- Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Abeta pathology and improves cognitive function
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Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL
- KMID: 1402318
- Exp Mol Med.
- 2012 Dec;44(12):740-748.
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the... -
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