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Carpinus turczaninowii extract modulates arterial inflammatory response: a potential therapeutic use for atherosclerosis

Son YK, Yoon SR, Bang WY, Bae CH, Yeo JH, Yeo R, An J, Song J, Kim OY

BACKGROUND/OBJECTIVES: Vascular inflammation is an important feature in the atherosclerotic process. Recent studies report that leaves and branches of Carpinus turczaninowii (C. turczaninowii) have antioxidant capacity and exert anti-inflammatory effects....
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Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro

He MT, Lee AY, Park CH, Cho EJ

BACKGROUND/OBJECTIVES: Excessive production of reactive oxygen species (ROS) such as hydroxyl (·OH), nitric oxide (NO), and hydrogen peroxide (H2O2) is reported to induce oxidative stress. ROS generated by oxidative stress...
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4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages

Yoo OK, Keum YS

We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage...
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Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective

Sidorov E, Sanghera D, Vanamala J

Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find...
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Effect of Blood Donation on the Donor's Hemorheological Properties

Lee BK

The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood,...
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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats

Kang C, Kim DH, Kim T, Lee SH, Jeong JH, Lee SB, Kim JH, Jung MH, Lee KW, Park IS

OBJECTIVE: Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in...
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Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder

Dokumacioglu E, Demiray O, Dokumacioglu A, Sahin A, Sen TM, Cankaya S

PURPOSE: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative...
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Evaluation of prooxidant-antioxidant balance in in vitro fertilization-conceived mice

Ahmadi H, Fathi F, Moeini A, Amidi F, Sobhani A

OBJECTIVE: Concerns about the safety of assisted reproductive technology (ART) have been raised, as some studies have shown elevated incidence rates of childhood cancer, asthma, allergies, and other diseases in...
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A survey of research papers on the health benefits of kimchi and kimchi lactic acid bacteria

Kim B, Mun EG, Kim D, Kim Y, Park Y, Lee HJ, Cha YS

PURPOSE: This review article provides an overview of the trends of research papers on the health benefits of kimchi and kimchi lactic acid bacteria published from 1995 to 2017. METHODS: All...
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Pharmacologic Characteristics of Corticosteroids

Samuel S, Nguyen T, Choi HA

Corticosteroids (CSs) are used frequently in the neurocritical care unit mainly for their anti-inflammatory and immunosuppressive effects. Despite their broad use, limited evidence exists for their efficacy in diseases confronted...
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Effect of iron overload with ascorbic acid on experimental colon carcinogenesis in mice

Ahn TH, Kim SJ, Jeong JH, Nam SY, Yun YW, Lee BJ

Excessive iron can promote the production of free radicals, thereby leading to harmful effects on cancer and aging. Ascorbic acid is not only an antioxidant but also a co-factor of...
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Apoptosis and remodeling in adriamycin-induced cardiomyopathy rat model

Hong YM, Lee H, Cho MS, Kim KC

PURPOSE: The mechanism for the pathogenesis of adriamycin (ADR)-induced cardiomyopathy is not yet known. Different hypotheses include the production of free radicals, an interaction between ADR and nuclear components, and...
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Antimutagenic and Antioxidant Activities of Thai Rice Brans

Insuan O, Chariyakornkul A, Rungrote Y, Wongpoomchai R

BACKGROUND: Rice bran is the outer layer of the rice grain, and contains high amounts of bioactive phytochemicals. Here, we investigated and compared chemopreventive properties of purple and white rice...
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Dietary Antioxidant Capacity and Its Association with Preeclampsia

Sheikhi M, Sharifi-Zahabi E, Paknahad Z

Preeclampsia (PE) is one of the major disorders in pregnancy leading to many adverse maternal outcomes. Although the etiology of PE is not fully understood, resent studies suggest that an...
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Treatment of Leukocytospermia in Male Infertility: A Systematic Review

Jung JH, Kim MH, Kim J, Baik SK, Koh SB, Park HJ, Seo JT

Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in up to 15% of male infertility. Leukocytospermia is...
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Toll-Like Receptor-Mediated Free Radical Generation in Clonorchis sinensis Excretory-Secretory Product-Treated Cholangiocarcinoma Cells

Bahk YY, Pak JH

Clonorchiasis, caused by direct contact with Clonorchis sinensis worms and their excretory-secretory products (ESPs), is associated with chronic inflammation, malignant changes in bile ducts, and even cholangiocarcinogenesis. Our previous report...
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Melatonin Protects Human Adipose-Derived Stem Cells from Oxidative Stress and Cell Death

Tan SS, Han X, Sivakumaran P, Lim SY, Morrison W

BACKGROUND: Adipose-derived stem cells (ASCs) have applications in regenerative medicine based on their therapeutic potential to repair and regenerate diseased and damaged tissue. They are commonly subject to oxidative stress...
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Cytoprotective Effect of Polyphenolic Compounds against Oxidative Stress in Cultured Retinal Pigment Epithelial Cells

Seo KH, Yu SY, Kwak HW

PURPOSE: Grape seed-derived polyphenols (GSPs) provide a concentrated source of polyphenols having antioxidant capacity. In this study we investigated the cytoprotective effect of GSP against oxidative stress-induced cell damage in...
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Noise-Induced Neural Degeneration and Therapeutic Effect of Antioxidant Drugs

Choi SH, Choi CH

The primary site of lesion induced by noise exposure is the hair cells in the organ of Corti and the primary neural degeneration occurs in synaptic terminals of cochlear nerve...
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Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

Paillard T, Rolland Y, de Souto Barreto P

Alzheimer's disease (AD) and Parkinson's disease (PD) are devastating, frequent, and still incurable neurodegenerative diseases that manifest as cognitive and motor disorders. Epidemiological data support an inverse relationship between the...
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