Korean Circ J.  1996 Feb;26(1):112-123. 10.4070/kcj.1996.26.1.112.

Adrenergic Effects on the Cardiac Damage by Oxygen Free Radicals

• Song YS
• Kim SK

• KMID: 2093570
• DOI: http://doi.org/10.4070/kcj.1996.26.1.112

Abstract

BACKGROUND
It is now well known that oxygen free radicals act as mediators of cellular injury in many cardiovascular diseases. Although some evidences have been presented for an altered number of adrenergic receptors in heart disease, a detailed examination of the interaction of free radicals with cardiac adrenergic receptors has little been carried out.
METHODS
This study is therefore undertaken to examine the influences of adrenergic blocking agents(propranolol, prazosin) and cyclooxygenase inhibitor(aspirin) on the cardiac damage by oxygen free radicals. Ischemic condition of the isolated rat heart was made by Langendorff preparation, and then measured superoxide dismutase(SOD), lactate dehydrogenase(LDH) released in the perfusate, and malondialdhyde(MDA) concentration in the cardiac tissue.
RESULTS
We obtained the results that increased SOD activity and tendency of decreased LDH activity by the pretreatment of propranolol, prazosin, and aspirin in cardiac ischemic-reperfusion injury. Those effects were more predominant in adriamycin treated group comparing with not treated group.
CONCLUSION
Adrenergic blocking agent, propranolol, prazosin, and aspirin seem to have some protective effect on the reperfusion injury of the heart.

Keyword

Adrenergic blocking agent; Oxygen free radical

MeSH Terms

Adrenergic Agents*
Animals
Aspirin
Cardiovascular Diseases
Doxorubicin
Free Radicals*
Heart
Heart Diseases
Lactic Acid
Oxygen*
Prazosin
Propranolol
Prostaglandin-Endoperoxide Synthases
Rats
Receptors, Adrenergic
Reperfusion Injury
Superoxides
Adrenergic Agents
Aspirin
Doxorubicin
Free Radicals
Lactic Acid
Oxygen
Prazosin
Propranolol
Prostaglandin-Endoperoxide Synthases
Receptors, Adrenergic
Superoxides