- Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN/LPS-induced hepatitic ICR mice
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Park CM, Song YS
- KMID: 2464126
- Nutr Res Pract.
- 2019 Dec;13(6):473-479.
- doi: 10.4162/nrp.2019.13.6.473
BACKGROUND/OBJECTIVES: Anti-inflammatory and antioxidative activities of luteolin and luteolin-7-O-glucoside were compared in galactosamine (GalN)/lipopolysaccharide (LPS)-induced hepatitic ICR mice. MATERIALS/METHODS: Male ICR mice (6 weeks old) were divided into 4 groups: normal... -
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- Anti-inflammatory effect of remifentanil in lipopolysaccharide–stimulated amniotic epithelial cells
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Kim CH, Jeong SS, Park SJ, Choi EJ, Kim YH, Ahn JH
- KMID: 2461241
- J Dent Anesth Pain Med.
- 2019 Oct;19(5):253-260.
- doi: 10.17245/jdapm.2019.19.5.253
BACKGROUND: Sometimes general anesthesia is required for dental surgery in pregnant women. Facial bone fractures or neck abscess should be treated immediately. Dental surgery, however, creates a stressful situation that... -
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- Diverse characters of Brennan’s paw incision model regarding certain parameters in the rat
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Kumar R, Gupta S, Gautam M, Jhajhria S, Ray SB
- KMID: 2455612
- Korean J Pain.
- 2019 Jul;32(3):168-177.
- doi: 10.3344/kjp.2019.32.3.168
BACKGROUND: Brennan’s rodent paw incision model has been extensively used for understanding mechanisms underlying postoperative pain in humans. However, alterations of physiological parameters like blood pressure and heart rate, or... -
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- Effect of Garcinia mangostana L. and propolis extracts on the inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats
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Sung SJ, Kang KM, Lee KH, Yoo SY, Kook JK, Lee DS, Yu SJ
- KMID: 2452748
- Int J Oral Biol.
- 2019 Jun;44(2):55-61.
- doi: 10.11620/IJOB.2019.44.2.55
The purpose of this study was to evaluate the effect of mangosteen extract complex (MEC; Garcinia mangostana L. and propolis extracts) on the inhibition of inflammation and prevention of alveolar... -
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- Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats
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Yin Y, Park H, Lee SY, Lee WH, Song HJ, Kim J, Kim DW, Hong J
- KMID: 2451071
- Exp Neurobiol.
- 2019 Jun;28(3):352-361.
- doi: 10.5607/en.2019.28.3.352
Neuroinflammation is one of the key mechanisms of neuropathic pain, which is primarily mediated by the Toll-like receptor 4 (TLR4) signaling pathways in microglia. Therefore, TLR4 may be a reasonable... -
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- Anti-inflammatory activities of sinensetin on LPS-stimulated L6 skeletal muscle cells
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Kim JA, Ha SE, Kim SM, Vetrivel P, Kim GS, Kim EH
- KMID: 2448283
- J Biomed Transl Res.
- 2019 Mar;20(1):1-7.
- doi: 10.12729/jbtr.2019.20.1.001
Inflammation is an important protective response mechanism that occurs against microbial invasion or injury. However, excessive inflammation may lead to cause of morbidity and mortality in diseases. The activated macrophages... -
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- Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
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Zhao D, Gu MY, Xu JL, Zhang LJ, Ryu SY, Yang HO
- KMID: 2432072
- Biomol Ther.
- 2019 Jan;27(1):92-100.
- doi: 10.4062/biomolther.2018.104
Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this... -
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- rBMSCs/ITGA5B1 Promotes Human Vascular Smooth Muscle Cell Differentiation via Enhancing Nitric Oxide Production
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Zhang Y, Ding J, Xu C, Yang H, Xia P, Ma S, Chen H
- KMID: 2429549
- Int J Stem Cells.
- 2018 Nov;11(2):168-176.
- doi: 10.15283/ijsc18079
BACKGROUND AND OBJECTIVES: Previous studies have shown that integrins alpha5beta1 (ITGA5B1) gene-modified rat bone marrow mesenchymal stem cells (rBMSCs) could prevent cell anoikis and increase the nitric oxide (NO) production.... -
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- From Gut to Brain: Alteration in Inflammation Markers in the Brain of Dextran Sodium Sulfate-induced Colitis Model Mice
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Do J, Woo J
- KMID: 2428972
- Clin Psychopharmacol Neurosci.
- 2018 Nov;16(4):422-433.
- doi: 10.9758/cpn.2018.16.4.422
OBJECTIVE: Neuropsychiatric manifestations like depression and cognitive dysfunction commonly occur in inflammatory bowel disease (IBD). In the context of the brain-gut axis model, colitis can lead to alteration of brain... -
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- A New Medical Therapy for Axial Spondyloarthritis
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Lee SY, Lee SH
- KMID: 2446983
- Korean J Med.
- 2018 Oct;93(5):424-429.
- doi: 10.3904/kjm.2018.93.5.424
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the first choice of treatment for axial spondyloarthritis (axSpA); cyclooxygenase (COX)-2 inhibitors reduce both inflammation and bone formation. When NSAID treatment fails, tumor necrosis... -
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- Nonsteroidal anti-inflammatory drug hypersensitivity in the Asia-Pacific
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Thong BY
- KMID: 2423989
- Asia Pac Allergy.
- 2018 Oct;8(4):e38.
- doi: 10.5415/apallergy.2018.8.e38
Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity reactions (HSRs) are often nonimmunologically mediated reactions which present with immediate HSR type manifestations. These are mediated by cyclooxygenase inhibition resulting in shunting towards the... -
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- Strategies for the safe use of non-steroidal anti-inflammatory drugs
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Ahn GY, Bae SC
- KMID: 2414145
- J Korean Med Assoc.
- 2018 Jun;61(6):367-375.
- doi: 10.5124/jkma.2018.61.6.367
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in various clinical situations, with excellent analgesic, anti-pyretic and anti-inflammatory effects. In addition to gastrointestinal bleeding, which was the first adverse effect to... -
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- Pulegone Exhibits Anti-inflammatory Activities through the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-stimulated RAW 264.7 cells
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Roy A, Park HJ, Abdul QA, Jung HA, Choi JS
- KMID: 2409606
- Nat Prod Sci.
- 2018 Mar;24(1):28-35.
- doi: 10.20307/nps.2018.24.1.28
Pulegone is a naturally occurring organic compound obtained from essential oils from a variety of plants. The aim of this study was to investigate the anti-inflammatory effects through the inhibitory... -
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- Estragole Exhibits Anti-inflammatory Activity with the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-induced RAW 264.7 cells
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Roy A, Park HJ, Jung HA, Choi JS
- KMID: 2409604
- Nat Prod Sci.
- 2018 Mar;24(1):13-20.
- doi: 10.20307/nps.2018.24.1.13
Estragole is a naturally occurring phenylpropanoid obtained from essential oils found in a broad diversity of plants. Although the phenylpropanoids show many biological activities, clear regulation of the inflammatory signaling... -
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- Chemoprevention of Gastric Cancer: Non-steroidal Anti-inflammatory Drugs Including Aspirin
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Choi KD
- KMID: 2397489
- Korean J Helicobacter Up Gastrointest Res.
- 2017 Dec;17(4):169-174.
- doi: 10.7704/kjhugr.2017.17.4.169
Many reports have been published that provide epidemiological evidence supporting the efficacy of aspirin and non-steroidal anti- inflammatory drugs (NSAIDs) in cancer prevention. The presumed mechanism of chemoprevention is inhibition... -
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- The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery
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Hao N, Zhaojun W, Kuang S, Zhang G, Deng C, Ma J, Cui J
- KMID: 2395253
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):591-598.
- doi: 10.4196/kjpp.2017.21.6.591
Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol... -
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- Expression of the genes for peroxisome proliferator-activated receptor-γ, cyclooxygenase-2, and proinflammatory cytokines in granulosa cells from women with polycystic ovary syndrome
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Lee JY, Tae JC, Kim CH, Hwang D, Kim KC, Suh CS, Kim SH
- KMID: 2390493
- Clin Exp Reprod Med.
- 2017 Sep;44(3):146-151.
- doi: 10.5653/cerm.2017.44.3.146
OBJECTIVE: To identify differences in the expression of the genes for peroxisome proliferator-activated receptor (PPAR)-γ, cyclooxygenase (COX)-2, and the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in granulosa... -
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- Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats
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Guevara-Balcazar G, Ramirez-Sanchez I, Mera-Jimenez E, Rubio-Gayosso I, Aguilar-Najera ME, Castillo-Hernandez MC
- KMID: 2384454
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):407-413.
- doi: 10.4196/kjpp.2017.21.4.407
Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine... -
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- Elucidation of the profound antagonism of contractile action of phenylephrine in rat aorta effected by an atypical sympathomimetic decongestant
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Rizvić E, Janković , Savić MM
- KMID: 2384452
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):385-395.
- doi: 10.4196/kjpp.2017.21.4.385
Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decongestants and possible source of adverse responses. Insufficiently substantiated practice of combining decongestants in some marketed preparations,... -
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- Falcarindiol from Angelica koreana Down-regulated IL-8 and Up-regulated IL-10 in Colon Epithelial Cells
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Shim SY, Lee SG, Kim M, Lee JW, Hwang BY, Lee M
- KMID: 2387059
- Nat Prod Sci.
- 2017 Jun;23(2):103-107.
- doi: 10.20307/nps.2017.23.2.103
Angelica koreana is an important medicinal plant for some locals in East Asia including Korea. A few reports have shown the efficacy of its phytochemical constituents. We have isolated and... -
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