Korean J Gastroenterol.  2000 Feb;35(2):154-162.

The Role of Neutrophil on Nonsteroidal Anti-Inflammatory Drugs Induced Acute Gastric Mucosal Injury

• Yun BY
• Kim JH
• Lee HJ
• Jang BI
• Kim TN
• Chung MK
• Choi JH

Abstract

BACKGROUND/AIMS
Gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is one of the most frequent adverse reactions. However, the precise mechanism of such injury remains still unclear. The present study was designed to determine the role of neutrophils in NSAIDs-induced acute gastric mucosal injury.
METHODS
Indomethacin was used as cyclooxygenase inhibitor. Methotrexate induced neutropenia in rat. Indomethacin was administered to neutropenic rats and controls and then, their acute gastric mucosal injury was assessed. Mucosal eicosanoid formation and gastric mucosal injury were assessed in neutropenic rats or leucovorin "rescue" rats receiving indomethacin. RESULTS: Gastric mucosal lesion induced by indomethacin were significantly reduced in the rats which had been in moderate neutropenic state induced by methotrexate. Moreover, in the methotrexate-induced neutropenia rats, the neutropenia-associated mucosal protection effect against indomethacin-induced mucosal injury could be deserved of leucovorin rescue. Indomethacin caused a significant reduction in gastric mucosal prostaglandin synthesis. Thus, little gastric mucosal lesions were observed in neutropenic rats that were treated with indomethacin, despite the significant inhibition of prostaglandin synthesis. CONCLUSIONS: These results suggest that neutrophil takes part in indomethacin-induced acute gastric mucosal injury

Keyword

Acute gastric mucosal injury; Nonsteroidal anti-inflammatory drugs; Neutrophil

MeSH Terms

Animals
Indomethacin
Leucovorin
Methotrexate
Neutropenia
Neutrophils*
Prostaglandin-Endoperoxide Synthases
Rats
Indomethacin
Leucovorin
Methotrexate
Prostaglandin-Endoperoxide Synthases