Korean J Helicobacter Up Gastrointest Res.  2017 Dec;17(4):169-174. 10.7704/kjhugr.2017.17.4.169.

Chemoprevention of Gastric Cancer: Non-steroidal Anti-inflammatory Drugs Including Aspirin

• Choi KD

• KMID: 2397489
• DOI: http://doi.org/10.7704/kjhugr.2017.17.4.169

Abstract

Many reports have been published that provide epidemiological evidence supporting the efficacy of aspirin and non-steroidal anti- inflammatory drugs (NSAIDs) in cancer prevention. The presumed mechanism of chemoprevention is inhibition of cyclooxygenase (COX)-2. Aspirin exhibits an anticancerous effect through several inter-related mechanisms: prostaglandin synthesis and catabolism in epithelial cells, inhibition of Wnt-β-catenin signaling, inactivation of platelets, and the host immune response. Several clinical studies have demonstrated that aspirin and NSAIDs exhibit chemopreventive effects in stomach cancer. However, well-designed clinical studies to answer critical clinical questions such as additional benefits of aspirin or NSAIDs after eradication of Helicobacter pylori, and the net benefit despite the adverse effects of long-term intake of aspirin or NSAIDs, are needed.

Keyword

Anti-inflammatory agents, non-steroidal; Aspirin; Chemoprevention; Stomach neoplasms

MeSH Terms

Anti-Inflammatory Agents, Non-Steroidal
Aspirin*
Chemoprevention*
Epithelial Cells
Helicobacter pylori
Metabolism
Prostaglandin-Endoperoxide Synthases
Stomach Neoplasms*
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Prostaglandin-Endoperoxide Synthases