Korean J Gastrointest Endosc.  2009 Dec;39(6):379-383.

Multiple Gastrointestinal Drug Induced Ulcers Associated with Aspirin and Non-steroidal Anti-inflammatory Drugs: A Case Report and Review of the Literature

• Kim HJ
• Chung WC
• Lee KM
• Paik CN
• Jung SH
• Kim JD
• Jung SH
• Kwak JW

Abstract

Aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed drugs, and they are known to be responsible for many cases of gastroduodenal ulcerations by inhibiting prostaglandin synthesis via blocking the cyclo-oxygenase production. Colonic side effects of these drugs are rare, but they are increasingly being reported to be due to the popularization of colonoscopy and the new formulations of drugs such as enteric coated pills or slow release pills. There is currently no consensus for making the clinical diagnosis and administering the proper therapy for drug-induced colonopathy in Korea. We experienced the patient who had multiple colonic ulcers after ingesting large amounts of aspirin and NSAIDs. In near future, we hope to determine the clinical and endoscopic features of drug associated colon injury.

Keyword

Aspirin; Non-steroidal anti-inflammatory drug; Colon ulcer

MeSH Terms

Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Colon
Colonoscopy
Consensus
Humans
Korea
Peptic Ulcer
Prostaglandin-Endoperoxide Synthases
Ulcer
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Prostaglandin-Endoperoxide Synthases