J Korean Ophthalmol Soc.
1991 Nov;32(11):964-969.
The Role of Prostaglandins in Surgically Induced Miosis
- Affiliations
-
- 1The First Eye Center, Daegu, Korea.
- 2Department of Ophthalmology, College of Medicine, Yeungnam University, Daegu, Korea.
Abstract
- In cataract surgery, the surgically induced miosis complicate the removal of lens materials and implantation of a posterior chamber intraocular lens, which increase the risk of ocular trauma and its associated complication. The refore maintenance of mydriasis during cataract syrgery makes the operation easier and brings a good results. This study was performed in rabbit and human eyes to assess the role of the prostaglandins in surgically induced miosis by observing the reduction of pupillary constriction and by measuring the amount of prostaglandins in aqueous humor when the 1.0% suprofen, cyclo-oxygenase inhibitor, was used, and to assess the effect of suprofen in intraocular pressure. In the results, suprofen inhibits syrgically induced miosis (p value: <0.01, human <0.01) without intraocular pressure change, and for this miosis, prostaglans and for this miosis, prostaglandins are at least partially responsible.
