J Asthma Allergy Clin Immunol.  2000 Jun;20(3):545-550.

A case of acetaminophen induced bronchial asthma without aspirin sensitivity

Affiliations
  • 1Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Abstract

Acetaminophen is a widely used analgesic-antipyretic. Hypersensitivity reactions to acetaminophen are rare and selective sensitivity to acetaminophen without aspirin or non-steroidal antiinflammatory drug intolerance is even rarer. We experienced a case of acetaminopheninduced bronchial asthma without aspirin sensitivity. An oral challenge test upto 650mg of Tylenol demonstrated urticaria and dyspnea with greater than 20% decrease of FEV1. Both oral provocation test with 500mg of aspirin and lysine-aspirin bronchoprovocation test showed negative results. In conclusion, we report a case of acetaminophen-induced asthma without aspirin sensitivity. Cyclo-oxygenase inhibition may not be a pathogenic mechanism of acetaminophen-induced bronchial asthma. Further studies will be needed to clarify the mechanism of this reaction.

Keyword

Acetaminophen-induced asthma; oral provocation test

MeSH Terms

Acetaminophen*
Aspirin*
Asthma*
Dyspnea
Hypersensitivity
Prostaglandin-Endoperoxide Synthases
Urticaria
Acetaminophen
Aspirin
Prostaglandin-Endoperoxide Synthases
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