Korean J Asthma Allergy Clin Immunol.  2006 Dec;26(4):318-321.

A Case of Propyphenazone Induced Asthma without Aspirin Sensitivity

Abstract

Propyphenazone (1,2-dihydro-1,5-dimethyl-4-(isopropyl)-2- phenyl-pyrazol-3-one: isopropylantipyrine) is a nonsteroidal anti-inflammatory drug (NSAID) and widely used as a mild analgesic. Allergy-like reactions, such as urticaria, anaphylaxis, hemolytic anemia and serum sickness, have been regarded as pseudoallergic or intolerant reactions to this drug. Herein we report a case with propyphenazone-induced bronchoconstriction without cross-reaction with aspirin or acetaminophen. A 33-year-old female patient presented with cough and dyspnea which aggravated after taking NSAID compounds containing propyphenazone. To find the component inducing bronchial hyperresponsiveness, oral provocation tests were performed with aspirin, acetaminophen, NSAID compounds containing propyphenazone, and pure propyphenazone, respectively. After an oral challenge with NSAID compound containing propyphenazone or pure propyphenazone (150 mg), she showed significant changes in FEV1. However, an oral provocation test with aspirin (500 mg) or acetaminophen (900 mg) demonstrated negative results. This case was confirmed as asthma induced by propyphenazone without aspirin and acetaminophen sensitivity.

MeSH Terms

Acetaminophen
Adult
Anaphylaxis
Anemia, Hemolytic
Anti-Inflammatory Agents, Non-Steroidal
Aspirin*
Asthma*
Bronchoconstriction
Cough
Drug Hypersensitivity
Dyspnea
Female
Humans
Serum Sickness
Urticaria
Acetaminophen
Anti-Inflammatory Agents, Non-Steroidal
Aspirin