J Asthma Allergy Clin Immunol.  2002 Mar;22(1):100-108.

Prevalence of aspirin sensitivity among asthmatic patients with mild to moderate severity and its clinical characteristics

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, drmin@snu.ac.kr
  • 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Abstract

BACKGROUND: While aspirin sensitivity has been known to be common among patients with severe asthma, its frequency among asthmatics with mild to moderate severity remains to be learned.
OBJECTIVES
To elucidate the frequency of aspirin sensitivity and its clinical characteristics among asthma patients with mild to moderate severity. MATERIAL AND METHODS: A total of 96 asthmatics with mild to moderate severity were enrolled. They underwent lysine-aspirin and methacholine bronchial provocation tests, and gave their induced sputum after the lysine-aspirin challenge.
RESULTS
FEV1 declined greater than 20% compared with baseline FEV1 in 11 of 96 patients on the lysine-aspirin challenge. The frequency of aspirin sensitivity was higher among patients with enhanced bronchial hyperresponsiveness to methacholine (PC20 < 1 mg/ml) than among those without it (27.3% vs. 6.8%). The frequency was also higher in those with induced sputum eosinophil count higher than 3% than among those without it (38.9% vs. 0%). However, it was not associated with other risk factors such as age, sex, atopy, nasal polyps, and rhinosinusitis.
CONCLUSION
More than 10% of mild to moderate asthmatics have aspirin sensitivity even though they have experienced no history of aspirin sensitivity which may be related with bronchial hyperresponsiveness to methacholine and eosinophil activation.

Keyword

aspirin-induced asthma; mild to moderate asthma; induced sputum; eosinophil; airway hyperresponsiveness

MeSH Terms

Aspirin*
Asthma
Asthma, Aspirin-Induced
Bronchial Provocation Tests
Eosinophils
Humans
Methacholine Chloride
Nasal Polyps
Prevalence*
Risk Factors
Sputum
Aspirin
Methacholine Chloride
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