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Indoor pet ownership in infancy is a risk factor for the development of sensitization to pets and asthma in childhood

Jung S, Noh SR, Lee SY, Yoon J, Cho HJ, Kim YH, Suh DI, Yang SI, Kwon JW, Jang GC, Sun YH, Woo SI, Youn YS, Park KS, Lee E, Cho HJ, Kook MH, Yi HR, Chung HL, Kim JH, Kim HY, Jung JA, Woo HO, Hong SJ

PURPOSE: It is controversial whether indoor pet exposure is either a risk or protective factor developing sensitization to pet allergens or asthma. Therefore, we investigated whether indoor pet ownership entails...
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Value of Exhaled Nitric Oxide and FEF(25–75) in Identifying Factors Associated With Chronic Cough in Allergic Rhinitis

Liu X, Wang X, Yao X, Wang Y, Sun Y, Zhang L

PURPOSE: Chronic cough in allergic rhinitis (AR) patients is common with multiple etiologies including cough variant asthma (CVA), non-asthmatic eosinophilic bronchitis (NAEB), gastroesophageal reflux-related cough (GERC), and upper airway cough...
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Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children

Jung S, Suh DI, Lee SY, Yoon J, Cho HJ, Kim YH, Yang SI, Kwon JW, Jang GC, Sun YH, Woo SI, Youn YS, Park KS, Cho HJ, Kook MH, Yi HR, Chung HL, Kim JH, Kim HY, Jung JA, Woo HO, Hong SJ

BACKGROUND: A US Food and Drug Administration (FDA)-approved drug methacholine chloride (Provocholine®) was recently introduced to Korea where it is now widely used in clinical practice. We aimed to evaluate...
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Methacholine bronchial provocation test in patients with asthma: serial measurements and clinical significance

Seo HJ, Lee PH, Kim BG, Lee SH, Park JS, Lee J, Park SW, Kim DJ, Park CS, Jang AS

BACKGROUND/AIMS: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical...
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Dyspnea Perception During Induced Bronchoconstriction Is Complicated by the Inhaled Methacholine in Children With Clinical Asthma

Choi YJ, Suh DI, Sohn MH, Koh YY

PURPOSE: Dyspnea is not widely utilized as an indicator of asthma provocation despite its universal presentation. We hypothesized that dyspnea severity was proportionate with the lung function decline, methacholine dose-step,...
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The KAAACI Standardization Committee Report on the procedure and application of the bronchial provocation tests

Lim KH, Kim MH, Yang MS, Song WJ, Jung JW, Lee J, Suh DI, Shin YS, Kwon JW, Kim SH, Kim SH, Lee BJ, Cho SH, Korean Academy of Asthma, Allergy and Clinical Immunology Standardization Committee

Bronchial provocation tests are of value in the evaluation of airway hyperresponsiveness. Nonspecific bronchial challenge (methacholine, mannitol, exercise, etc.) is used when the symptoms, physical examination, and measurements of pulmonary...
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Comparison on the profiles of a modified Borg scale and the pediatric dyspnea scale during an induced bronchoconstriction in children with clinical asthma

Kim YS, Shin J, Choi YJ, Song JH, Lee JK, Oh HL, Suh DI, Koh YY

PURPOSE: Dyspnea is the cardinal symptom of asthma, but it is difficult to quantify clinically. Although modified Borg (mBorg) scale has been successfully used in adult, but there has been...
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Usefulness of House Dust Mite Nasal Provocation Test in Asthma

Choi IS, Kim SJ, Won JM, Park MS

PURPOSE: We previously reported that the skin prick test was sensitive and the serum specific immunoglobulin E test was specific for predicting positive airway responses to house dust mites (HDMs)...
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Relationship between atopy and bronchial hyperresponsiveness to indirect stimuli in asthmatic children

Park TY, Yi MJ, Choi WH, Kim SY, Yu R, Ban JE, Yang S, Hwang IT, Baek HS

PURPOSE: Both atopy and bronchial hyperresponsiveness (BHR) are characteristic features of asthma. Several BHR studies comparing groups of atopic and nonatopic asthmatics have reported conflicting results. The aim of this...
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Nonspecific Bronchoprovocation Test

Lee MK, Yoon HK, Kim SW, Kim TH, Park SJ, Lee YM

Bronchial asthma is a disease characterized by the condition of airway hyper-responsiveness, which serves to produce narrowing of the airway secondary to airway inflammation and/or various spasm-inducing stimulus. Nonspecific bronchoprovocation...
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Induction of Bronchial Tolerance After 1 Cycle of Monophosphoryl-A-Adjuvanted Specific Immunotherapy in Children With Grass Pollen Allergies

Rosewich M, Girod K, Zielen S, Schubert R, Schulze J

PURPOSE: Subcutaneous allergen-specific immunotherapy (SCIT) is a well-established and clinically effective method to treat allergic diseases, such as rhinitis and asthma. It remains unclear how soon after initiation of an...
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Comparison between exhaled nitric oxide and bronchial challenge with methacholine or adenosine-5'-monophosphate in the diagnosis of childhood asthma

Yoon J, Park JS, Cho HJ, Lee E, Yang SI, Hong SJ, Yu J

PURPOSE: Asthma is a chronic airway inflammatory disease characterized by bronchial hyperresponsiveness and reversible airway obstruction. Bronchial challenge with methacholine or adenosine-5'-monophosphate (AMP) has been used to diagnose asthma. Recently,...
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The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis

Zhang L, Zhang L, Zhang CH, Fang XB, Huang ZX, Shi QY, Wu LP, Wu P, Wang ZZ, Liao ZS

OBJECTIVES: Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been...
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Comparison of short-term effects between subcutaneous and sublingual immunotherapies in children with house dust mite-sensitized allergic rhinitis and asthma

Lee E, Kim MJ, Yang SI, Yu J, Hong SJ

PURPOSE: There have been several studies on comparisons of efficacy between subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in children with house dust mite (HDM)-sensitized allergic rhinitis (AR), without consistent...
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Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey

Myung JH, Seo HJ, Park SJ, Kim BY, Shin IS, Jang JH, Kim YK, Jang AS

BACKGROUND/AIMS: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify...
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The safety and efficacy of recombinant fibroblast growth factor 2 in human asthmatics: A pilot study

Kim YS, Jang YH, Jeon JH, Seo JH, Kang SH, Jee YK

PURPOSE: Fibroblast growth factor 2 (FGF2) has been shown to inhibit airway inflammation, mucus production, and airway hyperresponsiveness in mouse model of asthma. The aim of this study was to...
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The prevalence of bronchial hyperresponsiveness in elementary school children and its associated factors

Kim MS, Kim YH, Suh DI, Koh YY, Kim BJ, Kim HB, Lee SY, Song DJ, Kim WK, Jang GC, Shim JY, Hong SJ, Kwon JW

PURPOSE: We investigated the prevalence of bronchial hyperresponsiveness (BHR) and its associated factors in population-based elementary school children. METHODS: Methacholine bronchial provocation tests were performed on 1,151 elementary school children and...
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Influence of Chronic Sinusitis and Nasal Polyp on the Lower Airway of Subjects Without Lower Airway Diseases

Lee SY, Yoon SH, Song WJ, Lee SH, Kang HR, Kim SS, Cho SH

PURPOSE: Upper and lower respiratory tract pathologies are believed to be interrelated; however, the impact of upper airway inflammation on lung function in subjects without lung disease has not been...
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Association of insulin resistance with bronchial hyperreactivity

Kim KM, Kim SS, Lee SH, Song WJ, Chang YS, Min KU, Cho SH

BACKGROUND: Several epidemiologic studies showed the significant association of insulin resistance with asthma. OBJECTIVE: The aim of this study was to evaluate the association of insulin resistance with airway hyperresponsiveness (AHR)...
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Factors Affecting Bronchial Hyperresponsiveness in Rhinitis Patients

Son HR, Lee JH, Chung YJ, Mo JH

BACKGROUND AND OBJECTIVES: Many studies have revealed a close relationship between allergic rhinitis (AR) and asthma. This study was designed to evaluate clinical parameters affecting bronchial hyperresponsiveness (BHR) in patients...
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