Korean J Intern Med.  1996 Jun;11(2):157-160.

Complete resolution of airway hyperresponsiveness in aspirin-sensitive asthmatic patients

• Park HS

Abstract

Appreciable numbers of aspirin-sensitive asthmatic patients have chronic steroid-dependent severe asthmatic symptoms. We report four cases of aspirin-sensitive asthmatics who had mild to severe asthmatic symptoms, whose methacholine PC20 level ranged from 0.6 to 22 mg/ml at the first visit. The aspirin sensitivity was confirmed by lysine-aspirin bronchoprovocation. After anti-asthmatic medications and avoidance of salicylate-containing agents, airway hyperresponsiveness and respiratory symptoms disappeared for two to 30 months. These results suggest that early detection and careful avoidance of salicylate-containing agents may have a beneficial effect resulting in the resolution of airway hyperresponsiveness in aspirin-sensitive asthmatic patients.

MeSH Terms

Adult
Aspirin/adverse effects*
Asthma/physiopathology*
Bronchoconstriction/drug effects*
Female
Human
Male
Middle Age