J Korean Neurosurg Soc.
1990 Sep;19(8-9):1210-1220.
Effect of Allopurinol on Brain Infarction Following Middle Cerebral Artery Occlusion in Rats
- Affiliations
-
- 1Department of Neurosurgery, College of Medicine, Korea University, Seoul, Korea.
Abstract
- Of the many potential source of free radial generation, the enzyme xanthine oxidase has been shown to be important in ischemia in non-cerebral tissues. Oxygen-derived free radicals have been implicated in various pathological conditions including ischemia. Xanthine oxidase serve as a source of oxidizing agents such as superoxide radical and hydrogen peroxide. It is investigated that the effect of a specific xanthine oxidase inhibitor, allopurinol, on infarct size in a model of continuous partial cerebral ischemia in rats. Infarct volume was measured by triphenyl tetrazolium chloride staining of brains removed 24 hours after middle cerebral arterial occlusion. Cortical tissue was more effectively protected than basal tissue, especially in allopurinol pretreated group. On histological examinations, hemispheric swelling, PMN cell infiltration and endothelial damage were noted irrespective of allopurinol treatment. It was speculated that free radicals are important in infarction secondary to partial continuous cerebral ischemia and that xanthine oxidase may by the primary source of these radicals.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- The Neuroprotective Effects of Woohwangcheongsim-won on Cerebral Ischemia following the Middle Cerebral Artery Occlusion in Rats
- Traumatic Occlusion of the Middle Cerebral Artery
- Effect of Cervical Sympathectomy on Ischemic Brain Damage Induced by Focal Cerebral Infarction in Rats
- The Effect of Isoflurane and Propofol upon Focal Cerebral Ischemia
- The Effect of U-74389G and MK-801 on the Size of Brain Infarction in the Transient Focal Ischemia-Reperfusion Rat Model
