Korean J Anesthesiol.  1991 Dec;24(6):1083-1089. 10.4097/kjae.1991.24.6.1083.

The Effect of Isoflurane and Propofol upon Focal Cerebral Ischemia

• Park CM

• KMID: 2237055
• DOI: http://doi.org/10.4097/kjae.1991.24.6.1083

Abstract

The effect of isoflurane and propofol anesthesia upon the infarct size after middle cerebral artery occlusion was studied using 18 male Sprague-Dawley rat. The infarct area was calculated using Quantimet autoradiography and compared between conscious control and anesthe-tized rats. The results were as follows; 1) Slightly increased volume of infarction was noted in anesthetized rat with no significancy compare to conscious control rats, but the caudate nucleus revealed statistically significant increased vloume of infarction in isoflurane anesthesia rats. 2) The protective effect for cerebral ischaemia of isoflurane or propofol seems insignificant, but we can use them in the neuroanesthetic field without difficulty because they do not increase the infarcted volume. 3) Durging iaoflurane anesthesia the elevated brain glucose and glucose-6-phosphate may increase neurological damage after ischaemia. Furthermore the change of CBF/Metabolism relationship may affect to the infarction.

Keyword

Cerebral protection; Isoflurane; Propofol

MeSH Terms

Anesthesia
Animals
Autoradiography
Brain
Brain Ischemia*
Caudate Nucleus
Glucose
Glucose-6-Phosphate
Humans
Infarction
Infarction, Middle Cerebral Artery
Isoflurane*
Male
Propofol*
Rats
Rats, Sprague-Dawley
Glucose
Glucose-6-Phosphate
Isoflurane
Propofol