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Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours

Lee H, Choi S, Jang EJ, Lee J, Kim D, Yoo S, Oh SY, Ryu HG

Background: The purpose of this study was to assess the correlation between sedatives and mortality in critically ill patients who required mechanical ventilation (MV) for ≥ 48 hours from 2008...
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Effects of etomidate use in ICU patients on ventilator therapy: a study of 12,526 patients in an open database from a single center

Park HY, Lee Y, Lim CY, Kim M, Park J, Lee T

Background: There is a debate regarding the safety of etomidate. We evaluated the effects of etomidate on mortality in a large cohort of critical care patients. Methods: This retrospective matched-cohort study...
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Pain Intensity at Injection Site during Esophagogastroduodenoscopy Using Long- and MediumChain versus Long-Chain Triglyceride Propofol: A Randomized Controlled Double-Blind Study

Lee JS, Kim ES, Cho KB, Park KS, Lee YJ, Lee JY

Background/Aims: The intensities of injection pain resulting from the use of long- and mediumchain triglyceride (LCT/MCT) propofol and conventional LCT propofol during esophagogastroduodenoscopy (EGD) have yet to be compared. We...
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Procedural Sedation for Pediatric Upper Gastrointestinal Endoscopy in Korea

Lee YM, Kang B, Kim YB, Kim HJ, Lee KJ, Lee Y, Choi SY, Lee EH, Yi DY, Jang HJ, Choi YJ, Hong SJ, Kim JY, Kang Y, Kim SC

Background: Sedative upper endoscopy is similar in pediatrics and adults, but it is characteristically more likely to lead to respiratory failure. Although recommended guidelines for pediatric procedural sedation are available...
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Safety and Recipient Satisfaction of Propofol Sedation in Outpatient Endoscopy: A 24-Hour Prospective Investigation Using a Questionnaire Survey

Kanno Y, Ohira T, Harada Y, Koshita S, Ogawa T, Kusunose H, Koike Y, Yamagata T, Sakai T, Masu K, Yonamine K, Miyamoto K, Tanaka M, Shimada T, Kozakai F, Endo K, Okano H, Komabayashi D, Shimizu T, Suzuki S, Ito K

Background/Aims: The aim of this study was to evaluate the safety of sedation with propofol as an alternative to benzodiazepine drugs in outpatient endoscopy. Methods: In this prospective study, examinees who...
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Intraoperative refractory status epilepticus caused by propofol -a case report-

Kumar A, Kumar A, Kumar N, Kumar A

Background: Status epilepticus, when continued despite the administration of two antiepileptic drugs, is called refractory status epilepticus (RSE). The seizure-like phenomenon due to propofol is widely reported in...
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The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation

Erdem KTO, Bedir Z, Ates I, Kuyrukluyildiz U, Coban TA, Yazici GN, Arslan YK, Suleyman Z, Suleyman H

Propofol infusion syndrome characterized by rhabdomyolysis, metabolic acidosis, kidney, and heart failure has been reported in long-term propofol use for sedation. It has been reported that intracellular adenosine triphosphate (ATP)...
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Efficacy and Safety of Etomidate in Comparison with Propofol or Midazolam as Sedative for Upper Gastrointestinal Endoscopy

Kim JH, Byun S, Choi YJ, Kwon HJ, Jung K, Kim SE, Park MI, Moon W, Park SJ

Background/Aims: In this study, we compared the efficacy and safety of etomidate with those of propofol or midazolam for the maintenance of sedation during endoscopy. Methods: The study enrolled patients who...
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Sedation for Brain Magnetic Resonance Imaging in Preterm Infants: Using Propofol under Anesthesiologist Supervision

Han YS, Kim HH, Kim HS, Yang MS, Ahn SY, Sung SI, Chang YS, Park WS

Purpose: We aimed to compare two different sedation protocols for brain magnetic resonance imaging (MRI) in preterm infants. One protocol used chloral hydrate (CH) with monitoring conducted by non-anesthesiologists, and...
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Effects of Sedation Performed by an Anesthesiologist on Pediatric Endoscopy: a Single-Center Retrospective Study in Korea

Yang SM, Yi DY, Choi GJ, Lim IS, Chae SA, Yun SW, Lee NM, Kim SY, Choi ES

Background: Endoscopy is used for diagnosing and treating various digestive diseases in children as well as in adults. However, in pediatric patients, it is recommended that sufficient sedation should be...
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Dexmedetomidine and propofol based totalintravenous anesthesia in a case of Joubert syndrome

Luthra A, Singh V

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Effect-site concentration of remifentanil for preventing propofol injection pain during induction of balanced anesthesia

Kim J, Kim D, Lee HG

Background: Despite various strategies designed for preventing pain from propofol injection, it is still common and distressing to the patients. The purpose of the present study was to investigate the...
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The immunosuppressive effects of volatile versus intravenous anesthesia combined with epidural analgesia on kidney cancer: a pilot randomized controlled trial

Efremov SM, Kozireva VS, Moroz GB, Abubakirov MN, Shkoda OS, Shilova AN, Yarmoshuk SV, Zheravin AA, Landoni G, Lomivorotov VV

Background: The aim of this study was to test the hypothesis that the use of inhalational anesthesia leads to higher suppression of the cell-mediated immunity compared to total intravenous...
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Continuous infusion versus intermittent bolus injection of propofol during endoscopic retrograde cholangiopancreatography

Lee JG, Yoo KS, Byun YJ

Background/Aims: It is unclear whether continuous infusion or intermittent bolus injection of propofol is better for achieving adequate sedation in endoscopic retrograde cholangiopancreatography (ERCP). We aimed to compare the efficacy...
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Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits

Sun Wc, Wang J, Cai D, Pei L

  • KMID: 2508472
  • Exp Neurobiol.
  • 2020 Oct;29(5):356-375.
  • doi: 10.5607/en20032
Dexmedetomidine (DEX) has neuroprotective effects and its efficacy was determined in propofol-treated pups. Postnatal day (P) 7 rats were exposed to propofol and DEX to investigate the induced apoptosis-related gene...
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Remifentanil-based propofol-supplemented vs. balanced sevoflurane-sufentanil anesthesia regimens on bispectral index recovery after cardiac surgery: a randomized controlled study

Sung TY, Lee DK, Bang J, Choi J, Shin S, Kim TY

Background: The present study was to compare the potential impact of remifentanil-based propofol-supplemented anesthesia regimen vs. conventional sevoflurane-sufentanil balanced anesthesia on postoperative recovery of consciousness indicated by c) values in...
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Easy sedation anesthesia guide for non-anesthetic medical personnel

Min TJ

Currently, sedation anesthesia is increasingly used in many medical fields, from gastroscopy to medical imaging. The demand for sedation anesthesia is expected to increase gradually with increasing number of day...
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Medium- and long-chain triglyceride propofol reduces the activity of acetyl-coenzyme A carboxylase in hepatic lipid metabolism in HepG2 and Huh7 cells

Wang LY, Wu J, Gao YF, Lin DM, Ma J

Medium- and long-chain triglyceride (MCT/LCT) propofol is widely used as an intravenous anesthetic, especially in the intensive care unit. The present study aimed to assess whether MCT/LCT propofol is safe...
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Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedation

Jun MR, Yoo JH, Park SY, Na S, Kwon H, Nho JH, Kim SI

BACKGROUND: Phase-lag entropy (PLE) was recently described as a measurement of temporal pattern diversity in the phase relationship between two electroencephalographic signals from prefrontal and frontal montages. This study was...
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Anesthetic management in corticobasal degeneration with central sleep apnea: A case report

Shionoya Y, Nakamura K, Sunada K

Corticobasal degeneration (CBD) is a rare neurodegenerative disease characterized by dystonia, cognitive deficits, and an asymmetric akinetic-rigid syndrome. Little information is available regarding anesthetic management for CBD patients. Our patient...
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