J Korean Neurosurg Soc.  2002 Sep;32(3):239-245.

Comparison of the Cerebral Protective Effects of Thiopental, Propofol and Dantrolene on Focal Cerebral Ischemia Induced by Temporary Middle Cerebral Artery Occlusion in the Rat Under the Monitoring of Compressed Spectral Array

• Kim JH
• Kim SH
• Min KT
• Kim MH
• Song SK
• Lee BH

Abstract

OBJECTIVE
We evaluate the cerebral protective effect of thiopental, propofol and dantrolene in middle cerebral artery occlusion(MCAO) model of rats, which ventilated spontaneously and showed definitely decreased EEG activities which is compatible with cerebral focal ischemia.
METHODS
Sprague-Dawley rats were anesthetized with halothane. In control group, halothane(1-1.3 vol%) was inhaled by mask. In thiopental and propofol group, halothane was switched to each drug about 20 minutes before MCAO. In dantrolene group, dantrolene was administered 20 minutes before MCAO with halothane inhalation. Middle cerebral artery was occluded for 120 minutes. The focal ischemic proess was confirmed by ipsilateral suppression of EEG, expressed by compressed spectral array. The volume percentage of infarcted brain was measured.
RESULTS
The percentage of infarct volume in thiopental group(13.7+/-4.6%) was significantly smaller than other groups(control group : 28.4+/-4.2%, propofol group:32.3+/-6.7%, dantrolene group : 31.9+/-5.4%). But, there was no statistically meaningful difference between control group, propofol group, and dantrolene group.
CONCLUSION
The results of this study indicate that only thiopental has brain protective effect against focal cerebral ischemia.

Keyword

Focal cerebral ischemia; Thiopental; Propofol; Dantrolene; Compressed spectral array

MeSH Terms

Animals
Brain
Brain Ischemia*
Dantrolene*
Electroencephalography
Halothane
Infarction, Middle Cerebral Artery*
Inhalation
Ischemia
Masks
Middle Cerebral Artery*
Propofol*
Rats*
Rats, Sprague-Dawley
Thiopental*
Dantrolene
Halothane
Propofol
Thiopental