Korean J Gastroenterol.
1997 Jul;30(1):66-71.
Activities of Hepatic Antioxidant Enzymes in Bile Duct Ligates Rats
Abstract
-
BACKGROUND AND AIMS: Protective role of antioxidant enzymes under the cholestasis was evaluated.
METHODS
: The activity of xanthine oxidase, the amount of superoxide radical production, and the activities of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase were measured under the cholestasis.
RESULTS
Xanthine oxidase activity, Vmax value of this enzyme and superoxide radical production were iricreased after CBD ligation. Superoxide dismutase arid glutathione peroxidase activities showed no significant changes throughout the experiments. Catalase activity and Vmax value of this enzyme in the liver was signifi-cantly decreased after CBD ligation.
CONCLUSIONS
Although the production of oxygen free radicals is increased due to increased xanthine oxidase, anti-oxidant enzymes do not play their protective role to oxygen free radicals due to decreased biosynthesis.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Relationship between Morphological Changes and the Level of Antioxidant Enzymes in Rat Hepatocytes after Bile Duct Obstruction
- Arylamine Acetyltransferase Activity from a Regenerating Liver after Partial Hepatectomy and from a Cholestatic Liver after Common Bile Duct Ligation in Rats
- Immunohistochemical Expression of Bcl-2 and Bax after Bile Duct Ligation in the Rat
- Thiosulfate sulfurtransferase and UDP-glucuronosyltransferase activities in cholestatic rat liver induced by common bile duct ligation
- Transmission electron microscopic findings of the intra-hepatic biliary tract after bile duct ligation in rats
