- The effect of insulin on glycogen synthase activity in individualskeletal muscle in rat
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Park SW, Suh KI, Kim JH, Park HS, Jang YJ, Lee KU
- KMID: 1699978
- J Korean Diabetes Assoc.
- 1991 Jun;15(1):35-40.
No abstract available. -
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- Skeletal Muscle Glycogen Synthase in the Pathogenesis of Insulin Resistance
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Park SW
- KMID: 2178004
- J Korean Diabetes Assoc.
- 1998 Jun;22(2):117-126.
No abstract available. -
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- The role of impaired response of skeletal muscle glycogen synthase activity to insulin in the pathogenesis of insulin resistance instreptozotocin induced diabetic rats
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Park SW, Suh KI, Park KS, Jang YJ, Lee KU
- KMID: 1699994
- J Korean Diabetes Assoc.
- 1991 Dec;15(2):183-188.
No abstract available. -
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- Suppression of Autophagy and Activation of Glycogen Synthase Kinase 3beta Facilitate the Aggregate Formation of Tau
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Kim SI, Lee WK, Kang SS, Lee SY, Jeong MJ, Lee HJ, Kim SS, Johnson GV, Chun W
- KMID: 2285415
- Korean J Physiol Pharmacol.
- 2011 Apr;15(2):107-114.
- doi: 10.4196/kjpp.2011.15.2.107
Neurofibrillary tangle (NFT) is a characteristic hallmark of Alzheimer's disease. GSK3beta has been reported to play a major role in the NFT formation of tau. Dysfunction of autophagy might facilitate... -
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- Insulin Resistance in Late Pregnant Rats
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Chun MH, Kim YW, Park SY, Kim JY, Lee SK
- KMID: 2320381
- Yeungnam Univ J Med.
- 1995 Dec;12(2):319-330.
- doi: 10.12701/yujm.1995.12.2.319
The influence of normal late pregnancy on insulin action and insulin secretion was studied in the Sprague-Dawley female rats. On 20th day after mating, intravenous glucose tolerance test(IVGTI) was performed in... -
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- Immunohistochemical Study on the Distribution of Glycogen Synthase Kinase (GSK) 3beta in the Central Nervous System of SOD1G93A Transgenic Mice
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Joo KM, Chung YH, Kim SS, Kim KY, Lee WB, Cha CI
- KMID: 1521308
- Korean J Phys Anthropol.
- 2007 Dec;20(4):355-362.
In the present study, we investigated influences of glycogen synthase kinase (GSK) 3beta on the development and/or progression of amyotrophic lateral sclerosis (ALS). We used transgenic mice expressing a human... -
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- Effects of chronic alcohol exposure on ischemia–reperfusion-induced acute kidney injury in mice: the role of β-arrestin 2 and glycogen synthase kinase 3
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Wang L, Zhu Y, Wang L, Hou J, Gao Y, Shen L, Zhang J
- KMID: 2386967
- Exp Mol Med.
- 2017 Jun;49(6):e347.
- doi: 10.1038/emm.2017.76
Little is known about the effects of chronic alcohol intake on the outcome of acute kidney injury (AKI). Hence, we examined the effects of chronic alcohol intake on the development... -
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- Post - Exercise Glycogen Supercompensation in Liver and Muscle after Glucose Ingestion in Rats
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Jeung HH, Ahn JC, Lee DC, Park SY, Lee SK
- KMID: 2336075
- J Korean Orthop Assoc.
- 1998 Jun;33(3):892-902.
The muscle glycogen is an important energy source for muscle contraction especially in prolonged exercise. One of the important factors for improvement of physical performance in athletes is the storage... -
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- Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis
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Park H, Lee M, Kim DW, Hong SY, Lee H
- KMID: 2378571
- Obstet Gynecol Sci.
- 2016 Nov;59(6):470-478.
- doi: 10.5468/ogs.2016.59.6.470
OBJECTIVE: Glycogen synthase kinase 3β (GSK3β) is a pluripotent protein kinase involved in the development of cancers through regulation of numerous oncogenic molecules. Cyclin D1, an important regulator of G1... -
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- Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus
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Chung KM, Kang W, Kim DG, Hong HJ, Lee Y, Han CH
- KMID: 1700786
- Korean J Vet Res.
- 2014 Mar;54(1):21-26.
Although benfotiamine has various beneficial anti-diabetic effects, the detailed mechanisms underlying the impact of this compound on the insulin signaling pathway are still unclear. In the present study, we evaluated... -
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- Effect of Troglitazone on Glycogen synthase Activity in Human skeletal Muscle Culture from Obese Non-Diabetic and Obese Non-insulin Dependent Diabetes Mellitus
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Carter LA, Ciaraldi T, Henry RR, Park KS, Lee HK
- KMID: 2137370
- J Korean Diabetes Assoc.
- 1997 Sep;21(3):254-261.
BACKGROUND: Skeletal muscle is the principal tissue of insulin resistance in obese and non-insulin dependent diabetic(NIDDM) subjects. Troglitazone, a member of thiazolidinedione class of compounds, has been shown to improve... -
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- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
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Kim Y, Kim J, Ahn M, Shin T
- KMID: 2390482
- Anat Cell Biol.
- 2017 Sep;50(3):207-213.
- doi: 10.5115/acb.2017.50.3.207
Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of... -
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- Increased Glycogen Synthase Kinase-3beta mRNA Level in the Hippocampus of Patients with Major Depression: A Study Using the Stanley Neuropathology Consortium Integrative Database
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Oh DH, Park YC, Kim SH
- KMID: 2315889
- Psychiatry Investig.
- 2010 Sep;7(3):202-207.
OBJECTIVE: Glycogen synthase kinase-3beta (GSK-3beta) has become recognized as a broadly influential enzyme affecting diverse range of biological functions, including gene expression, cellular architecture, and apoptosis. The results of previous... -
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- Metabolic Phenotype of Glycogen Synthase Gene Inhibition in Human Skeletal Muscle Cells
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Koh JJ, Park KS, Kim JM, Kim SY, Lee HK, Ciaraldi T, Henry RR
- KMID: 1539950
- J Korean Diabetes Assoc.
- 2000 Jun;24(3):331-339.
BACKGROUND: Glycogen synthase (GS) is the rate-limiting enzyme controlling non-oxidative glucose disposal in skeletal muscle. Reduction in GS activity and impaired insulin responsiveness are characteristic features of skeletal muscle in... -
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- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- Wnt and GSK3 Signaling Pathways in Bipolar Disorder: Clinical and Therapeutic Implications
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Muneer A
- KMID: 2378478
- Clin Psychopharmacol Neurosci.
- 2017 May;15(2):100-114.
- doi: 10.9758/cpn.2017.15.2.100
The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial... -
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- Mechanism of Insulin Resistance : Time Dependence of the Development of Insulin Resistance in High Fat Fed Rats
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Park KS, Lee KU, Park SW, Lee HK, Min HK
- KMID: 2008302
- J Korean Diabetes Assoc.
- 1997 Jun;21(2):168-175.
BACKGROUND: Increased FFA availability is known to induce insulin resistance by decrease in peripheral glucose utilization and increase in hepatic glucose procluction. However, there are conflicting results about the time... -
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- Role of Glycogen Synthase Kinase-3 in Motor Neuronal Cell Death Mechanism of in Vitro Familial ALS Model (G94A, A4V mutant motoneuron)
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Koh SH, Kim J, Kim MH, Yu HJ, Kim M, Kim HJ, Lee KW, Kim SH
- KMID: 2343148
- J Korean Neurol Assoc.
- 2005 Apr;23(2):249-256.
BACKGROUND: G93A or A4V mutations in the human Cu/Zn- superoxide dismutase gene (hSOD1) cause familial amyotrophic lateral sclerosis (fALS). However, it has not yet clearly understood how these bring about... -
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- Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis: evidenced by lithium treatment
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Ahn M, Kim J, Park C, Cho J, Jee Y, Jung K, Moon C, Shin T
- KMID: 2390426
- Anat Cell Biol.
- 2017 Mar;50(1):48-59.
- doi: 10.5115/acb.2017.50.1.48
Glycogen synthase kinase (GSK)-3β has been known as a pro-inflammatory molecule in neuroinflammation. The involvement of GSK-3β remains unsolved in acute monophasic rat experimental autoimmune encephalomyelitis (EAE). The aim of... -
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- Effect of Exercise Training on Insulin Sensitivity and Intracellular Glucose Metabolism in Skeletal Muscle of High Fat-fed Rats
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Kim CH, Park JY, Hong SK, Park KS, Lee HK, Lee KU
- KMID: 2178017
- J Korean Diabetes Assoc.
- 1998 Jun;22(2):231-242.
BACKGROUND: Insulin resistance is a major characteristic of non-insulin-dependent diabetes mellitus and obesity. Many studies have indicated that increased intake of fat are associated with obesity and insulin resistance. On... -
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