Hanyang Med Rev.  2013 May;33(2):77-82. 10.7599/hmr.2013.33.2.77.

Role of Reactive Oxygen Species in Cell Death Pathways

• Kang SW

• KMID: 2168234
• DOI: http://doi.org/10.7599/hmr.2013.33.2.77

Abstract

Reactive oxygen species (ROS) are the chemical species that includes the superoxide anion, hydrogen peroxide and hydrogen radical. These ROS are simply thought as a group of molecules harmful to cells because they oxidize proteins, lipids and DNA, and they mediate cell death including apoptosis or necrosis. On the other hand, ROS have been shown to act as essential intracellular second messengers for certain cytokines and growth factors. Although the importance of ROS in the execution of cell death is controversial, ROS are likely to be involved in the signal transduction mechanism for cell death as signaling intermediates in death receptor initiated signaling pathways, specifically in the tumor necrosis factor alpha-tumor necrosis factor receptor 1 (TNFalpha-TNFR1) pathway. In this review, using TNFalpha-TNFR as the model system, we attempt to address the involvement of intracellular ROS in TNFalpha induced cell death, including apoptosis, necrosis and an alternative form of programmed cell death, necroptosis.

Keyword

Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Apoptosis; Necrosis

MeSH Terms

Apoptosis
Cell Death
Cytokines
DNA
Hand
Hydrogen
Hydrogen Peroxide
Intercellular Signaling Peptides and Proteins
Necrosis
Proteins
Reactive Oxygen Species
Second Messenger Systems
Signal Transduction
Superoxides
Tumor Necrosis Factor-alpha
Cytokines
DNA
Hydrogen
Hydrogen Peroxide
Intercellular Signaling Peptides and Proteins
Proteins
Reactive Oxygen Species
Superoxides
Tumor Necrosis Factor-alpha

Figure

• 

  Fig. 1 TNFα induced formation of apoptotic and necroptotic signaling complexes. TNFR1, tumor necrosis factor receptor 1; TRADD, TNFR type 1-associated death domain protein; TRAF2, TNF receptor-associated factor 2; cIAP1, cellular inhibitor of apoptosis 1; JNK, c-Jun N-terminal kinase; RIP1, receptor-interacting protein 1; FADD, Fas-associated death domain; GSH, glutathione; MnSOD, manganese-dependent superoxide dismutase; PRx, peroxiredoxin-3; NF-κB, nuclear factor kappa-light-chain-enhancer of activator B cells; ROS, reactive oxygen species.

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