J Vet Sci.  2015 Jun;16(2):145-150. 10.4142/jvs.2015.16.2.145.

Evaluation of adjuvant effects of fucoidan for improving vaccine efficacy

Affiliations
  • 1Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea. jooh@jejunu.ac.kr

Abstract

Fucoidan is a sulfated polysaccharide derived from brown seaweed, including Fucus vesiculosus. This compound is known to have immunostimulatory effects on various types of immune cells including macrophages and dendritic cells. A recent study described the application of fucoidan as a vaccine adjuvant. Vaccination is regarded as the most efficient prophylactic method for preventing harmful or epidemic diseases. To increase vaccine efficacy, effective adjuvants are needed. In the present study, we determined whether fucoidan can function as an adjuvant using vaccine antigens. Flow cytometric analysis revealed that fucoidan increases the expression of the activation markers major histocompatibility complex class II, cluster of differentiation (CD)25, and CD69 in spleen cells. In combination with Bordetella bronchiseptica antigen, fucoidan increased the viability and tumor necrosis factor-alpha production of spleen cells. Furthermore, fucoidan increased the in vivo production of antigen-specific antibodies in mice inoculated with Mycoplasma hyopneumoniae antigen. Overall, this study has provided valuable information about the use of fucoidan as a vaccine adjuvant.

Keyword

antigen-specific antibody; fucoidan; spleen cells; vaccine adjuvant; vaccine antigen

MeSH Terms

Adjuvants, Immunologic/pharmacology
Animals
Antigens, Bacterial/*immunology
Bacterial Vaccines/administration & dosage/*immunology
Biomarkers/metabolism
Bordetella bronchiseptica/*immunology
Cells, Cultured
Cytokines/*metabolism
Female
Flow Cytometry
Fucus/*chemistry
Gene Expression Regulation/drug effects
Mice
Mice, Inbred BALB C
Mycoplasma hyopneumoniae/*immunology
Polysaccharides/*pharmacology
Spleen/metabolism
Adjuvants, Immunologic
Antigens, Bacterial
Bacterial Vaccines
Biomarkers
Cytokines
Polysaccharides
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