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Bordetella bronchiseptica is a potent and safe adjuvant that enhances the antigen-presenting capability of dendritic cells

Lee YJ, Han Y, Joo HG

We previously demonstrated that Bordetella bronchiseptica (B. bronchiseptica) antigen (Ag) enhances the Mycoplasma hyopneumoniae Ag-specific immune response. The focus of this study was whether acellular bacterin of B. bronchiseptica could...
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Vaccination with Klebsiella pneumoniae-derived extracellular vesicles protects against bacteria-induced lethality via both humoral and cellular immunity

Lee WH, Choi HI, Hong SW, Kim KS, Gho YS, Jeon SG

The emergence of multidrug-resistant Klebsiella pneumoniae highlights the need to develop preventive measures to ameliorate Klebsiella infections. Bacteria-derived extracellular vesicles (EVs) are spherical nanometer-sized proteolipids enriched with outer membrane proteins....
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Evaluation of adjuvant effects of fucoidan for improving vaccine efficacy

Kim SY, Joo HG

Fucoidan is a sulfated polysaccharide derived from brown seaweed, including Fucus vesiculosus. This compound is known to have immunostimulatory effects on various types of immune cells including macrophages and dendritic...
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Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines

Kim SH, Jang YS

Vaccination is one of the most successful applications of immunology and for a long time has depended on parenteral administration protocols. However, recent studies have pointed to the promise of...
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Microneedle patches for vaccine delivery

Suh H, Shin J, Kim YC

In today's medical industry, the range of vaccines that exist for administration in humans represents an eclectic variety of forms and immunologic mechanisms. Namely, these are the live attenuated viruses,...
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Expression of verocytotoxic Escherichia coli antigens in tobacco seeds and evaluation of gut immunity after oral administration in mouse model

Rossi L, Di Giancamillo A, Reggi S, Domeneghini C, Baldi A, Sala V, Dell'Orto , Coddens A, Cox E, Fogher C

Verocytotoxic Escherichia (E.) coli strains are responsible for swine oedema disease, which is an enterotoxaemia that causes economic losses in the pig industry. The production of a vaccine for oral...
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Protective effects and immunogenicity of Salmonella Enteritidis killed vaccine strains selected from virulent Salmonella Enteritidis isolates

Kang ZW, Won HK, Kim EH, Noh YH, Choi HW, Hahn TW

  • KMID: 1991811
  • Korean J Vet Res.
  • 2011 Mar;51(1):21-28.
Salmonella Enteritidis (SE) has been a major causative agent of food-borne human disease due to consumption of contaminated eggs and poultry meat. To prevent SE infection in poultry, and therefore...
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Generation of transgenic corn-derived Actinobacillus pleuropneumoniae ApxIIA fused with the cholera toxin B subunit as a vaccine candidate

Shin MK, Jung MH, Lee WJ, Choi PS, Jang YS, Yoo HS

Corn, one of the most important forage crops worldwide, has proven to be a useful expression vehicle due to the availability of established transformation procedures for this well-studied plant. The...
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Efficacy of strain RB51 vaccine in protecting infection and vertical transmission against Brucella abortus in Sprague-Dawley rats

Islam MA, Khatun MM, Baek BK, Lee SI

Immunizing animals in the wild against Brucella (B.) abortus is essential to control bovine brucellosis because cattle can get the disease through close contact with infected wildlife. The aim of...
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Cytokine response in Balb/c mice infected with Francisella tularensis LVS and the Pohang isolate

Kim EJ, Park SH, Choi YS, Shim SK, Park MY, Park MS, Hwang KJ

We investigated the immune response induced by the Francisella (F.) tularensis live vaccine strain (LVS) and the Pohang isolate. After the Balb/c mice were infected intradermally (i.d) with 2 x...
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A predictive model for the level of sIgA based on IgG levels following the oral administration of antigens expressed in Sacchromyces cerevisiae

Shin SJ, Shin SW, Choi EJ, Lee DY, Ahn JM, Yang MS, Jang YS, Yoo HS

  • KMID: 1090765
  • J Vet Sci.
  • 2005 Dec;6(4):305-309.
Oral vaccination may be the most efficient way of inducing an immune response at the remote mucosal site through the common mucosal immune network. Antigenspecific secretory IgA (sIgA) is the...
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Peptide Mimotopes of Neisseria meningitidis Group B Capsular Polysaccharide

Park I, Choi IH, Kim SJ, Shin JS

The antigenic similarity between Neisseria meningitidis group B (NMGB) capsular polysaccharide (PS) and human polysialic acid (PSA) has hampered the development of a NMGB PS-based vaccine. But the possibility of...
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Capsular polysaccharide typing of domestic mastitis-causing Staphylococcus aureus strains and its potential exploration of bovine mastitis vaccine developmen. I. capsular polysaccharide typing, isolation and purification of the strains

Han HR, Pak SI, Kang SW, Jong WS, Youn CJ

  • KMID: 1103475
  • J Vet Sci.
  • 2000 Jun;1(1):53-60.
One hundred seven isolates of Staphylococcus aureus from bovine mastitis were investigated for colony morphology in serum-soft agar (SSA), autoagglutination in salt, and capsular serotype. Capsular polysaccharide (CP) was purified...
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Evaluation of antibody responses to pneumococcal vaccines with ELISA and opsonophagocytic assay

Kim KH, Seoh JY

Antibodies to a capsular polysaccharide (PS) provide protection against Streptococcus pneumoniae which express the homologous capsular serotype, and pneumococcal vaccines are designed to induce antibodies in the capsular PS. Levels...
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Effects of Addition of Sugars on the Stability of Leptospira Vaccine

Seong I

  • KMID: 2082914
  • Korean J Infect Dis.
  • 1998 Dec;30(6):551-557.
BACKGROUND: Most of the current licensed viral and bacterial vaccines produced in the world are in the state of antigen suspension, and the immunogenicities of the vaccines can be maintained...
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Use of vaccine in the era of antimicrobial resistance: need of effective pneumococcal vaccines

Sohn YM

Streptococcus pneumoniae is an important pathogen causing invasive infections particularly in children. Penicillin-nonsusceptible pneumococci are very prevalent in Korea and a difficult problem in antimicrobial treatment. Immunization with effective vaccines...
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Effects of Addition of Sugars on the Stability of Hepatitis B Virus Vaccine

Seong I

  • KMID: 1541341
  • J Korean Soc Virol.
  • 1997 Dec;27(2):143-149.
Most of the current licenced hepatitis B vaccines are being produced by recombinant DNA technology in large fermentation cultures of Saccharomyces cerevisiae of yeast cells which carry the gene coded...
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Nitroblue Tetrazolium Reduction by Pseudoeosinophils from Rabbits Treated with Bacterial or Viral Vaccine

Chung SG, Shin JW

  • KMID: 1664111
  • J Korean Pediatr Soc.
  • 1979 Aug;22(8):671-680.
This study was undertaken to acquire some information concerning the mechanism for reduction of nitroblue tetrazolium (NBT) dye by neutrophils. Male rabbits weighing more than 2 kilograms were used in...
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