Gut Liver.
2015 May;9(3):381-387. 10.5009/gnl13439.
Cytokine Expression of Microscopic Colitis Including Interleukin-17
- Affiliations
-
- 1Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea. pys1109@eulji.ac.kr
- 2Department of Internal Medicine, Ewha University School of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, Yeungnam University School of Medicine, Daegu, Korea.
- 5Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 6Department of Internal Medicine, Yonsei University School of Medicine, Seoul, Korea.
- 7Department of Biochemistry, Eulji University School of Medicine, Seoul, Korea.
- 8Department of Pathology, Eulji University School of Medicine, Seoul, Korea.
- 9Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea.
- KMID: 2155646
- DOI: http://doi.org/10.5009/gnl13439
Abstract
- BACKGROUND/AIMS
Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the pathogenic mechanism of microscopic colitis.
METHODS
This study consisted of six patients with lymphocytic colitis, six patients with collagenous colitis, and six patients with functional diarrhea but normal pathology. We performed an immunohistochemical analysis of the colonic mucosal biopsies to assess the expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-kappaB, interferon-gamma, inducible nitric oxide synthase, and tumor necrosis factor-alpha. We compared the quantity score of immunohistochemical staining among the groups.
RESULTS
The microscopic colitis group showed significantly higher expression of cyclo-oxygenase-2, interleukin-17, nuclear factor-kappaB, and interferon-gamma compared with the control group. Cytokine expression was similar between collagenous colitis and lymphocytic colitis. However, the expression of cyclo-oxygenase-2 was higher in collagenous colitis.
CONCLUSIONS
Proinflammatory cytokines, including interleukin-17 and interferon-gamma, are highly expressed in microscopic colitis. The expression of cyclo-oxygenase-2 was higher in collagenous colitis than in lymphocytic colitis. This study is the first on interleukin-17 expression in microscopic colitis patients.
MeSH Terms
-
Biopsy
Colitis, Microscopic/*metabolism
Colon/pathology
Cyclooxygenase 2/*metabolism
Cytokines/metabolism
Diarrhea/metabolism
Humans
Interferon-gamma/metabolism
Interleukin-17/*metabolism
Intestinal Mucosa/pathology
NF-kappa B/metabolism
Nitric Oxide Synthase Type II/*metabolism
Tumor Necrosis Factor-alpha/metabolism
Cyclooxygenase 2
Cytokines
Interleukin-17
Interferon-gamma
NF-kappa B
Nitric Oxide Synthase Type II
Tumor Necrosis Factor-alpha
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