- Expression of Cyclooxygenase-2 and its Relationship to p53 Accumulation in Colorectal Cancers
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Lim SC, Lee TB, Choi CH, Ryu SY, Kim KJ, Min YD
- KMID: 724106
- Yonsei Med J.
- 2007 Jun;48(3):495-501.
- doi: 10.3349/ymj.2007.48.3.495
PURPOSE: Cyclooxygenase (COX)-2 is an inducible isoform responsive to cytokines, mitogens, and growth factors, and is believed to be an important enzyme related to colorectal cancer (CRC). Existing evidence suggests... -
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- Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma
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Kwon SH, Jeong SW, Jang JY, Lee JE, Lee SH, Kim SG, Kim YS, Cho YD, Kim HS, Kim BS, Jin SY
- KMID: 1392908
- Clin Mol Hepatol.
- 2012 Sep;18(3):287-294.
- doi: 10.3350/cmh.2012.18.3.287
BACKGROUND/AIMS: Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are up-regulated in hepatocellular carcinoma (HCC). To investigate the levels of COX-2 and VEGF expression in chronic hepatitis (CH), cirrhosis, and... -
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- Expressions and Clinical Significances of c-met, c-erbB-2, COX-2, and IL-6 in the Biliary Tract Cancers
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Joo HH, Song EY, Jin SH, Oh SH, Choi YK
- KMID: 937932
- Korean J Gastroenterol.
- 2007 Dec;50(6):370-378.
BACKGROUND/AIMS: c-met, c-erbB-2, interleukin (IL)-6, and cyclooxygenase (COX)-2 expressions are considered to be implicated in the carcinogenesis and progression of cholangiocarcinoma, but the molecular pathogenesis of cholangiocarcinoma is still... -
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- Impacts of Cytosolic Phospholipase A2, 15-Prostaglandin Dehydrogenase, and Cyclooxygenase-2 Expressions on Tumor Progression in Colorectal Cancer
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Lim SC, Cho H, Lee TB, Choi CH, Min YD, Kim SS, Kim KJ
- KMID: 1071420
- Yonsei Med J.
- 2010 Sep;51(5):692-699.
- doi: 10.3349/ymj.2010.51.5.692
PURPOSE: In addition to cyclooxygenase-2 (COX-2) which is related to prostaglandin E2 synthesis, other enzymes such as cytosolic phospholipase A2 (cPLA2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH)... -
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- Inhibition of LPS-induced cyclooxygenase 2 and nitric oxide production by transduced PEP-1-PTEN fusion protein in Raw 264.7 macrophage cells
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Lee SH, Lee YP, Kim SY, Jeong MS, Lee MJ, Kang HW, Jeong HJ, Kim DW, Sohn EJ, Jang SH, Kim YH, Kwon HJ, Cho SW, Park J, Eum WS, Choi SY
- KMID: 1072943
- Exp Mol Med.
- 2008 Dec;40(6):629-638.
- doi: 10.3858/emm.2008.40.6.629
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor. Although it is well known to have various physiological roles in cancer, its inhibitory effect on inflammation... -
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- Expression of Cyclooxygenase-2 and Bcl-2 in Human Gastric Adenomas
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Park JH, Kang KH, Kim SH, Lee JH, Cho CM, Kweon YO, Kim SK, Choi YH, Bae HI, Kim MS
- KMID: 1782230
- Korean J Intern Med.
- 2005 Sep;20(3):198-204.
- doi: 10.3904/kjim.2005.20.3.198
BACKGROUND: Cyclooxygenase (COX) -2 is the rate-limiting enzyme in prostaglandin synthesis. An increased expression has been implicated in the development and progression of human gastric cancers and colorectal adenomas and... -
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- 15-Deoxy-delta 12,14-ProstaglandinJ2 Regulates Dedifferentiation through Peroxisome Proliferator-Activated Receptor-gamma-Dependent Pathway but Not COX-2 Expression in Articular Chondrocytes
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Lee JH, Yu SM, Yoon EK, Lee WK, Jung JC, Kim SJ
- KMID: 1713299
- J Korean Med Sci.
- 2007 Oct;22(5):891-897.
- doi: 10.3346/jkms.2007.22.5.891
Peroxisome proliferator-activated receptors-gamma (PPAR-gamma) is critical for phenotype determination at early differentiation stages of mesenchymal cells, whereas its physiological role is unclear. Therefore, we investigated the role of 15-deoxy-delta 12,14-prostaglandinJ2... -
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- Cytokine Expression of Microscopic Colitis Including Interleukin-17
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Park E, Park YS, Park DR, Jung SA, Han DS, Jang BI, Kim YH, Kim WH, Jo YJ, Lee KH, Lee WM, Kim EK, Koo HS
- KMID: 2155646
- Gut Liver.
- 2015 May;9(3):381-387.
- doi: 10.5009/gnl13439
BACKGROUND/AIMS: Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the... -
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- VEGF as a Predictor for Response to Definitive Chemoradiotherapy and COX-2 as a Prognosticator for Survival in Esophageal Squamous Cell Carcinoma
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Yoon MS, Nam TK, Lee JS, Cho SH, Song JY, Ahn SJ, Chung IJ, Jeong JU, Chung WK, Nah BS
- KMID: 1777881
- J Korean Med Sci.
- 2011 Apr;26(4):513-520.
- doi: 10.3346/jkms.2011.26.4.513
We investigated the patterns of pretreatment expression of the epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and cyclooxygenase-2 (COX-2) by immunohistochemical staining and determined their correlation with... -
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- The Effect of Cyclooxygenase-2 Expression on Tumor Volume Response in Patients Treated with Radiotherapy for Uterine Cervical Cancer
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Kang MK, Park W, Choi YL, Cho EY, Ahn G, Nam H, Huh SJ, Ahn YC, Lim DH, Oh DR, Bae DS, Kim BG
- KMID: 1783150
- J Korean Med Sci.
- 2009 Dec;24(6):1170-1176.
- doi: 10.3346/jkms.2009.24.6.1170
We investigated the correlation between Cyclooxygenase-2 (COX-2) expression and the tumor response in patients with cervical cancer that were treated with curative radiotherapy (RT). Fifty-seven patients with squamous cell carcinoma... -
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