- Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells
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Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K
- KMID: 2155390
- Exp Mol Med.
- 2014 Dec;46(12):e125.
- doi: 10.1038/emm.2014.77
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have... -
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- Anti-inflammatory effects of IL-4 and IL-10 on Human Polymorphonuclear Leukocytes
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Lee SW, Hong YS, Chun CM, Moon JD, Kim SJ, Jung IC, Yoon YH, Lee BA, Moon SW, Choi SH, Moon CK
- KMID: 2157586
- J Korean Med Sci.
- 2002 Feb;17(1):7-14.
- doi: 10.3346/jkms.2002.17.1.7
Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear... -
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- Effects of Diet-Induced Mild Obesity on Airway Hyperreactivity and Lung Inflammation in Mice
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Jung SH, Kwon JM, Shim JW, Kim DS, Jung HL, Park MS, Park SH, Lee J, Lee WY, Shim JY
- KMID: 1798140
- Yonsei Med J.
- 2013 Nov;54(6):1430-1437.
- doi: 10.3349/ymj.2013.54.6.1430
PURPOSE: Obesity has been suggested to be linked to asthma. However, it is not yet known whether obesity directly leads to airway hyperreactivity (AHR) or obesity-induced airway inflammation associated with... -
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- Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level
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Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ
- KMID: 1421617
- J Korean Med Sci.
- 2012 Jun;27(6):644-652.
- doi: 10.3346/jkms.2012.27.6.644
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial... -
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- Cytokine Expression of Microscopic Colitis Including Interleukin-17
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Park E, Park YS, Park DR, Jung SA, Han DS, Jang BI, Kim YH, Kim WH, Jo YJ, Lee KH, Lee WM, Kim EK, Koo HS
- KMID: 2155646
- Gut Liver.
- 2015 May;9(3):381-387.
- doi: 10.5009/gnl13439
BACKGROUND/AIMS: Microscopic colitis is characterized by chronic watery diarrhea with specific pathological changes that can be diagnosed by microscopic examination. We performed immunohistochemical analysis of proinflammatory cytokines to investigate the... -
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- Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Augments Acute Lung Injury via Its Neutrophil Priming Effects
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Choi JC, Jung JW, Kwak HW, Song JH, Jeon EJ, Shin JW, Park IW, Choi BW, Kim JY
- KMID: 1713463
- J Korean Med Sci.
- 2008 Apr;23(2):288-295.
- doi: 10.3346/jkms.2008.23.2.288
Granulocyte macrophage-colony stimulating factor (GM-CSF) has immuno-stimulatory effects. We hypothesized that GM-CSF plays an important role both in lipopolysaccharide (LPS)- and hemorrhage-induced acute lung injury (ALI). We also postulated that... -
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- Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice
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Sozmen M, Devrim AK, Tunca R, Bayezit M, Dag S, Essiz D
- KMID: 1737610
- J Vet Sci.
- 2014 Mar;15(1):51-60.
- doi: 10.4142/jvs.2014.15.1.51
The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B1 (FB1) in BALB/c mice. The mice were divided into six groups... -
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- Anti-inflammatory effects of a Houttuynia cordata supercritical extract
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Shin S, Joo SS, Jeon JH, Park D, Jang MJ, Kim TO, Kim HK, Hwang BY, Kim KY, Kim YB
- KMID: 1093504
- J Vet Sci.
- 2010 Sep;11(3):273-275.
- doi: 10.4142/jvs.2010.11.3.273
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration.... -
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- The Effects of Antioxidants and Nitric Oxide Modulators on Hepatic Ischemic-Reperfusion Injury in Rats
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Rhee JE, Jung SE, Shin SD, Suh GJ, Noh DY, Youn YK, Oh SK, Choe KJ
- KMID: 1109759
- J Korean Med Sci.
- 2002 Aug;17(4):502-506.
- doi: 10.3346/jkms.2002.17.4.502
Ischemic-reperfusion injury (IRI) is thought to be caused by oxygen radicals. Nitric oxide (NO) also has been thought to play a key role in IRI. This experiment was designed to... -
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- Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion- induced liver injury by inhibiting NF-kappa B activation
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Wang J, Qiao L, Li Y, Yang G
- KMID: 1072949
- Exp Mol Med.
- 2008 Dec;40(6):686-698.
- doi: 10.3858/emm.2008.40.6.686
Intestinal ischemia-reperfusion (I/R) is an important event in the pathogenesis of multiple organ dysfunction syndrome (MODS). The aim of this study is to determine the effects of ginsenoside Rb1 on... -
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- Effect of Small Hairpin RNA Targeting Endothelin-Converting Enzyme-1 in Monocrotaline-Induced Pulmonary Hypertensive Rats
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Son JS, Kim KC, Kim BK, Cho MS, Hong YM
- KMID: 2157974
- J Korean Med Sci.
- 2012 Dec;27(12):1507-1516.
- doi: 10.3346/jkms.2012.27.12.1507
The purpose of this study was to investigate the therapeutic effects of small hairpin RNA (shRNA) targeting endothelin-converting enzyme (ECE)-1 in monocrotaline (MCT)-induced pulmonary hypertensive rats. Ninty-four Sprague-Dawley rats were... -
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- Breast-Feeding Protects Infantile Diarrhea Caused by Intestinal Protozoan Infections
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Abdel-Hafeez EH, Belal US, Abdellatif MZM, Naoi K, Norose K
- KMID: 1792142
- Korean J Parasitol.
- 2013 Oct;51(5):519-524.
This study investigated the effect of breast-feeding in protection against protozoan infection in infants with persistent diarrhea. Infants were classified into 2 groups; 161 breast-fed infants and the same number... -
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- Defective Erythropoiesis in Bone Marrow is a Mechanism of Anemia in Children with Cancer
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Kim MH, Lee JH, Wu CW, Cho SW, Lee KC
- KMID: 1101547
- J Korean Med Sci.
- 2002 Jun;17(3):337-340.
- doi: 10.3346/jkms.2002.17.3.337
Evaluation of the mechanism of anemia in cancer patients might help to select patients for the more efficient use of erythropoietin (EPO, a growth factor for erythroid precursor cells). For... -
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- Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer
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Kim YS, Lee HL, Lee KB, Park JH, Chung WY, Lee KS, Sheen SS, Park KJ, Hwang SC
- KMID: 1022170
- Korean J Intern Med.
- 2011 Sep;26(3):304-313.
- doi: 10.3904/kjim.2011.26.3.304
BACKGROUND/AIMS: Oxidative stress results in protein oxidation and is implicated in carcinogenesis. Sulfiredoxin (Srx) is responsible for the enzymatic reversal of inactivated peroxiredoxin (Prx). Nuclear factor E2-related factor 2 (Nrf2)... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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- Mast Cells in Allergic Asthma and Beyond
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Reuter S, Stassen M, Taube C
- KMID: 1779624
- Yonsei Med J.
- 2010 Nov;51(6):797-807.
- doi: 10.3349/ymj.2010.51.6.797
Mast cells have been regarded for a long time as effector cells in IgE mediated type I reactions and in host defence against parasites. However, they are resident in all... -
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- Preventive Effects of Oligomerized Polyphenol on Estradiol-Induced Prostatitis in Rats
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Kim DS, Lee EJ, Cho KS, Yoon SJ, Lee YH, Hong SJ
- KMID: 1758568
- Yonsei Med J.
- 2009 Jun;50(3):391-398.
- doi: 10.3349/ymj.2009.50.3.391
PURPOSE: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, NIH category III) accounts for 90-95% of prostatitis cases. However, standard treatment has not yet been established. It is known that polyphenols have... -
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- Metformin Reduces Bleomycin-induced Pulmonary Fibrosis in Mice
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Choi SM, Jang AH, Kim H, Lee KH, Kim YW
- KMID: 2468274
- J Korean Med Sci.
- 2016 Sep;31(9):1419-1425.
- doi: 10.3346/jkms.2016.31.9.1419
Metformin has anti-inflammatory and anti-fibrotic effects. We investigated whether metformin has an inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis in a murine model. A total of 62 mice were divided... -
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- Angiopoietin-1 Modified Human Umbilical Cord Mesenchymal Stem Cell Therapy for Endotoxin-Induced Acute Lung Injury in Rats
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Huang ZW, Liu N, Li D, Zhang HY, Wang Y, Liu Y, Zhang LL, Ju XL
- KMID: 2374208
- Yonsei Med J.
- 2017 Jan;58(1):206-216.
- doi: 10.3349/ymj.2017.58.1.206
PURPOSE: Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of endothelial permeability and leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord... -
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- Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats
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Choi YJ, Kim N, Lee JY, Nam RH, Seo JH, Lee S, Kim HJ, Choi YJ, Lee HS, Lee DH
- KMID: 2411960
- Gut Liver.
- 2016 May;10(3):348-355.
- doi: 10.5009/gnl14509
BACKGROUND/AIMS: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-L-cysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. METHODS: Sprague-Dawley rats... -
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