J Vet Sci.  2010 Sep;11(3):273-275. 10.4142/jvs.2010.11.3.273.

Anti-inflammatory effects of a Houttuynia cordata supercritical extract

• Shin S
• Joo SS
• Jeon JH
• Park D
• Jang MJ
• Kim TO
• Kim HK
• Hwang BY
• Kim KY
• Kim YB

• KMID: 1093504
• DOI: http://doi.org/10.4142/jvs.2010.11.3.273

Abstract

Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-alpha and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased TNF-alpha and PGE2. The suppressive activity of HSE on NO and PGE2 production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE2 pathways.

Keyword

carrageenan; dexamethasone; Houttuynia cordata extract; indomethacin; inflammation

MeSH Terms

Analysis of Variance
Animals
Anti-Inflammatory Agents/*pharmacology
Carrageenan
Cell Line, Tumor
Dexamethasone/pharmacology
Dinoprostone/metabolism
Drugs, Chinese Herbal/*pharmacology
Immunoenzyme Techniques
Indomethacin/pharmacology
Male
Mice
Mice, Inbred ICR
Nitric Oxide/metabolism
Signal Transduction/*drug effects
Therapeutic Irrigation
Tumor Necrosis Factor-alpha/metabolism

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