Nat Prod Sci.
2022 Mar;28(1):33-39. 10.20307/nps.2022.28.1.33.
Lignans and Macrolides from the Leaves of Houttuynia cordata with Inhibitory Activity against NO Production in Murine Macrophage RAW 264.7 Cells
- Affiliations
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- 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea
- KMID: 2528076
- DOI: http://doi.org/10.20307/nps.2022.28.1.33
Abstract
- Eight lignans (1-8) and two macrolides (9-10) were isolated from the CHCl 3 -soluble fraction of Houttuynia cordata Thumb (Saururaceae). Structures of isolates were elucidated by extensive spectroscopic methods. Fatty acid-derived macrolides (9-10) have rarely been reported from nature. All the isolates were tested for their inhibitory activities against NO production in RAW 264.7 cells stimulated by LPS. It was found that compounds 3 and 9 remarkably down-regulated LPS-induced NO production with IC 50 values, 5.4 and 40.3 μM, respectively, without cytotoxicity.
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