Lab Anim Res.  2012 Jun;28(2):137-140. 10.5625/lar.2012.28.2.137.

Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model

• Kim D
• Park D
• Kyung J
• Yang YH
• Choi EK
• Lee YB
• Kim HK
• Hwang BY
• Kim YB

• KMID: 1436714
• DOI: http://doi.org/10.5625/lar.2012.28.2.137

Abstract

Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-alpha (TNF-alpha) and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased PGE2. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase-2-PGE2 pathways.

Keyword

Carrageenan; inflammation; Houttuynia cordata; supercritical extract

MeSH Terms

Administration, Oral
Animals
Carrageenan
Cell Count
Dexamethasone
Dinoprostone
Exudates and Transudates
Houttuynia
Indomethacin
Inflammation
Injections, Intraperitoneal
Nitric Oxide
Rats
Tumor Necrosis Factor-alpha
Carrageenan
Dexamethasone
Dinoprostone
Indomethacin
Nitric Oxide
Tumor Necrosis Factor-alpha

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