Exp Neurobiol.  2012 Sep;21(3):94-100. 10.5607/en.2012.21.3.94.

Medaka Fish Parkinson's Disease Model

• Matsui H
• Gavinio R
• Takahashi

• KMID: 2134999
• DOI: http://doi.org/10.5607/en.2012.21.3.94

Abstract

The teleost fish has been widely used in creating neurodegenerative models. Here we describe the teleost medaka fish Parkinson's disease (PD) models we developed using toxin treatment and genetic engineering. 1-Methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA), proteasome inhibitors, lysosome inhibitors and tunicamycin treatment in our model fish replicated some salient features of PD: selective dopamine cell loss and reduced spontaneous movement with the last three toxins producing inclusion bodies ubiquitously in the brain. Despite the ubiquitous distribution of the inclusion bodies, the middle diencephalic dopaminergic neurons were particularly vulnerable to these toxins, supporting the idea that this dopamine cluster is similar to the human substantia nigra. PTEN-induced putative kinase 1 (PINK1) homozygous mutants also showed reduced spontaneous swimming movements. These data indicate that medaka fish can serve as a new model animal of PD. In this review we summarize our previous data and discuss future prospects.

Keyword

Parkinson's disease; medaka fish; dopaminergic neurons; model animal

MeSH Terms

Animals
Brain
Dopamine
Dopaminergic Neurons
Genetic Engineering
Humans
Inclusion Bodies
Lysosomes
Oryzias
Oxidopamine
Parkinson Disease
Phosphotransferases
Proteasome Inhibitors
Protein Kinases
Substantia Nigra
Swimming
Tunicamycin
Dopamine
Oxidopamine
Phosphotransferases
Proteasome Inhibitors
Protein Kinases
Tunicamycin