Ewha Med J.  1996 Jun;19(2):221-226. 10.12771/emj.1996.19.2.221.

Striatal Network Model in Parkinson Disease: Preliminary Study

• Choi KG
• Park KD

• KMID: 1964701
• DOI: http://doi.org/10.12771/emj.1996.19.2.221

Abstract

OBJECTIVE
To construct the neural network model in the striatum that can explain the clin-ical effect of Parkinson disease.
METHODS
We use an approach to studying the function of neural systems that is based on the use of a class of computer models known as parallel distributed processors(PDPs).And the focus of this study is the nigrostriatal dopaminergic effects on the corticostriatal fibers and the striatal medium spiny neurons.
RESULTS
A model that explains hypokinesia in Parkinson disease is presented for the opation of the striatum.
CONCLUSIONS
In order to study the brain funcion and mechanism of physiopathology, te-stable theories that consider brain as a whole system are needed. We think neural network model with PDPs would be an important field in neuroscience in near future.

Keyword

Neural network; Parallel distributed processors; Parkinson disease

MeSH Terms

Brain
Computer Simulation
Dopamine Agents
Hypokinesia
Neural Networks (Computer)
Neurons
Neurosciences
Parkinson Disease*
Dopamine Agents