Ewha Med J.  1996 Jun;19(2):221-226. 10.12771/emj.1996.19.2.221.

Striatal Network Model in Parkinson Disease: Preliminary Study

Affiliations
  • 1Department of Neurosurgery, Ewha Womans University Medical School, Korea.

Abstract


OBJECTIVE
To construct the neural network model in the striatum that can explain the clin-ical effect of Parkinson disease.
METHODS
We use an approach to studying the function of neural systems that is based on the use of a class of computer models known as parallel distributed processors(PDPs).And the focus of this study is the nigrostriatal dopaminergic effects on the corticostriatal fibers and the striatal medium spiny neurons.
RESULTS
A model that explains hypokinesia in Parkinson disease is presented for the opation of the striatum.
CONCLUSIONS
In order to study the brain funcion and mechanism of physiopathology, te-stable theories that consider brain as a whole system are needed. We think neural network model with PDPs would be an important field in neuroscience in near future.

Keyword

Neural network; Parallel distributed processors; Parkinson disease
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