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Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism

Shin HW, Hong SW, Youn YC

Parkinsonism is a clinical syndrome presenting with bradykinesia, tremor, rigidity, and postural instability. Nonmotor symptoms have recently been included in the parkinsonian syndrome, which was traditionally associated with motor symptoms...
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The Effect of Depression on Quality of Life in Patients with Parkinson's Disease: Mediating Effect of Family Function

Bae ES, Kang HS

Purpose: The purpose of this study is to explore the roles and function of family in mediating the relationship between depression and quality of life of patients with Parkinson’s disease...
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Severity of Daytime Sleepiness and Parkinsonian-Like Symptoms in Korean Adults Aged 50–64 Years

Shin C, Kim REY, Thomas RJ, Yun CH, Lee SK, Abbott RD

Background and Purpose While excessive daytime sleepiness can predate Parkinson’s disease in late-life, its association with parkinsonian-like (P-L) symptoms in middle age are unknown. Since neurodegeneration can appear decades before...
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Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice

Kim SH, Hwang L, Jin JJ, Ko IG, Kim YB, Yoon HS, Baek SS

Purpose: Exercise is a representative noninvasive treatment that can be applied to various diseases. We studied the effect of resistance exercise on motor function and spatial learning ability in Parkinson...
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Effects of Diabetes Mellitus on the Risk of Parkinson Disease: An Updated Meta-Analysis with Cohort Studies

Yeom S, Yang Y, Kang JH

Purpose: This meta-analysis was conducted to analyze the effect of Diabetes Mellitus (DM) on the risk of Parkinson Disease (PD). Methods: Original prospective observational studies were searched through PubMed, Cumulative...
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Electroconvulsive Therapy for Parkinson’s Disease with Depression and Neuroleptic Malignant Syndrome: A Case Report

Mori Y, Miura I, Nozaki M, Osakabe Y, Izumi R, Akama T, Kimura S, Yabe H

Parkinson’s disease is often complicated by psychiatric symptoms. Psychiatrists are caught in a dilemma between such symptoms and physical treatment since Parkinson’s disease sometimes shows treatment resistance based on pharmacological...
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Ameliorative Effects of NXP031 on MPTP-Induced Neurotoxicity

Lee JH, Song MK, Kim YJ

Purpose: The purpose of this study was to investigate effects of NXP031, an inhibitor of oxidation by specifically binding to the complex of DNA aptamer/vitamin C, on dopaminergic neurons loss...
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Effect of Coffee, Tobacco, and Alcohol on Parkinson’s Disease

Seol W, Kim H, Son I

Since the neuroprotective effects of coffee and tobacco on Parkinson’s disease have been reported more than 50 years ago, clinical studies using caffeine and nicotine that were presumed as effective...
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Impact of the Choice of Cross-Validation Techniques on the Results of Machine Learning-Based Diagnostic Applications

Tougui I, Jilbab A, Mhamdi JE

Objectives: With advances in data availability and computing capabilities, artificial intelligence and machine learning technologies have evolved rapidly in recent years. Researchers have taken advantage of these developments in healthcare...
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Netrin-1/receptors regulate the pathogenesis in Parkinson’s diseases

Ahn EH, Kang SS, Ye K

The netrins and their receptors (deleted in colorectal cancer [DCC] and unc-5 netrin receptors A–D [UNC5A–D]) play essential roles for central nervous system (CNS) development, mediating axonal and neuronal navigation....
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In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-Omethyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease

Levodopa (L-DOPA) therapy is normally practised to treat motor pattern associated with Parkinson disease (PD). Additionally, several inhibitory drugs such as Entacapone and Opicapone are also cosupplemented to protect peripheral...
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Clinical Significance of ReceptorInteracting Protein 3 and Parkin, Essential Molecules for Necroptosis, in Breast Cancer

Won KY, Min SY, Song JY, Lim SJ, Han SA

Purpose: Receptor-interacting protein 3 (RIP3) is the main initiator of necroptosis. Parkin prevents the formation of the RIP1–RIP3 complex by promoting polyubiquitination of RIP3. However, the mechanism by which necroptosis...
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Effects of Taro Extract on Brain Resilience in In Vitro Parkinson’s Disease Model Induced by 6-Hydroxydopamine

Cho H, Kang K

Purpose: The purpose of this study was to investigate the effects of taro extract on brain resilience in in vitro Parkinson’s disease model induced by 6-hydroxydopamine (6-OHDA). Methods: To induce...
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Feasibility of Transcranial Direct Current Stimulation in Patients with Deep Brain Stimulation: a Case Report

Eun JD, Bang YM, Youn J, Cho JW, Kim YH, Chang WH

Although deep brain stimulation (DBS) has been reported to be effective to ameliorate motor and non-motor dysfunctions, freezing of gait (FoG) is often resistant to DBS in patients with Parkinson's...
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Analysis of Smartphone Recordings in Time, Frequency, and Cepstral Domains to Classify Parkinson’s Disease

Tougui I, Jilbab A, Mhamdi JE

Objectives: Parkinson’s disease (PD) is the second most common neurodegenerative disorder; it affects more than 10 million people worldwide. Detecting PD usually requires a professional assessment by an expert, and...
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Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis

Holla VV, Neeraja K, Surisetti BK, Prasad S, Kamble N, Srinivas D, Yadav R, Pal PK

Objective The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges in the management of patients with deep brain stimulation (DBS). We...
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Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease

Paff M, Loh A, Sarica C, Lozano AM, Fasano A

Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson’s disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design...
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Neurodegenerative Dementias: A Brief Review

Sin MK, Khemani P

Purpose: The purpose of this paper is to provide nurses with a concise review on neurodegenrative dementias. This review includes pathophysiology, clinical course, and tips on management of dementias from...
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Smoking Cessation, Weight Change, and Risk of Parkinson’s Disease: Analysis of National Cohort Data

Kim R, Yoo D, Jung YJ, Han K, Lee JY

Background and Purpose: To determine whether the postcessation weight gain modifies the protective effect of smoking on the development of Parkinson’s disease (PD). Methods: This nationwide cohort study included 3,908,687 Korean...
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Long-term Effects of Bilateral Subthalamic Deep Brain Stimulation on Postural Instability and Gait Difficulty in Patients with Parkinson’s Disease

Shin HW, Kim MS, Kim SR, Jeon SR, Chung SJ

Objective The long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on postural instability and gait difficulty (PIGD) in patients with Parkinson’s disease (PD) remain unclear. In this study,...
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