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Restless Legs Syndrome in Parkinson's Disease Patients: Clinical Features Including Motor and Nonmotor Symptoms

You S, Jeon SM, Do SY, Cho YW

BACKGROUND AND PURPOSE: We investigated the frequency and clinical features of restless legs syndrome (RLS) in patients with Parkinson's disease (PD). METHODS: This study included 74 PD patients. RLS was diagnosed...
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Expanding the Spectrum of Dopa-Responsive Dystonia (DRD) and Proposal for New Definition: DRD, DRD-plus, and DRD Look-alike

Lee WW, Jeon B, Kim R

Previously, we defined DRD as a syndrome of selective nigrostriatal dopamine deficiency caused by genetic defects in the dopamine synthetic pathway without nigral cell loss. DRD-plus also has the same...
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Malignant Neuroleptic Syndrome following Deep Brain Stimulation Surgery of Globus Pallidus Pars Internus in Cerebral Palsy

Lee JM, Paek SH, Park HR, Lee KH, Shin CW, Park HY, Park HP, Kim DG, Jeon BS

Neuroleptic malignant syndrome (NMS) is a rare but potentially lethal outcome caused by sudden discontinuation or dose reduction of dopaminergic agents. We report an extremely rare case of NMS after...
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Recovery from a Complicated Case of Central Pontine and Extrapontine Myelinolysis by Dopaminergic Treatment: One-Year Follow-up: A Case Report

Seo YJ, Im S, Oh CH, Park GY, Ko SB, Lee YJ

Central pontine and extrapontine myelinolysis are well-recognized osmotic demyelination syndromes related to the rapid correction of hyponatremia, chronic alcoholism, and malnutrition. They are reported to show brain stem signs and...
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Anti-Allodynic Effects of Levodopa in Neuropathic Rats

Park HJ, Joo HS, Kim YH, Kwon OK, Lee J, Kim ES, Moon DE

PURPOSE: Levodopa is the most effective anti-Parkinsonian agent. It has also been known to exhibit analgesic properties in laboratory and clinical settings. However, studies evaluating its effects on neuropathic pain...
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Diagnosis and Treatment of Restless Legs Syndrome

Jung KY

Restless legs syndrome (RLS) is a sensorimotor neurologic disorder, in which the primary symptom is a compelling urge to move the legs accompanied by unpleasant and disturbing sensations in the...
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Sleep-Related Eating Disorder

Park YM

  • KMID: 2317498
  • Sleep Med Psychophysiol.
  • 2011 Jun;18(1):5-9.
Sleep-related eating disorder (SRED) is a newly recognized parasomnia that describes a clinical condition of compulsive eating under an altered level of consciousness during sleep. Recently, it is increasingly recognized...
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Parkinsonism Associated with Glucocerebrosidase Mutation

Sunwoo MK, Kim SM, Lee S, Lee PH

BACKGROUND: Gaucher's disease is an autosomal recessive, lysosomal storage disease caused by mutations of the beta-glucocerebrosidase gene (GBA). There is increasing evidence that GBA mutations are a genetic risk factor...
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Pharmacologic Treatment of Restless Legs Syndrome

Kim SW, Jang JE, Kim SY, Kim JM, Shin IS, Yang SJ, Yoon JS

  • KMID: 2287443
  • Korean J Psychopharmacol.
  • 2010 Jan;21(1):14-21.
Restless legs syndrome (RLS) is defined as the urge to move one's legs, accompanied by unpleasant sensations in one's limbs, and is typically more severe at night. Sleep hygiene measures...
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One Case of Parkinson's Syndrome in a Shipyard Painter Exposed to Mixed Organic Solvents

Jo MH, Ryu HW, Kim EA

  • KMID: 2075050
  • Korean J Occup Environ Med.
  • 2009 Jun;21(2):192-200.
BACKGROUND: It is well-known that organic solvents can cause various neurologic toxicities, and in particular, it had been reported that Parkinson's syndrome can be caused by organic solvents. CASE REPORT: A...
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Pathologic Gambling in Parkinson Disease

Lee SA, Ahn TB, Lee YH, Lee DK, Kim JH

  • KMID: 2065671
  • J Korean Neurol Assoc.
  • 2008 May;26(2):149-151.
Pathologic gambling (PG) is an impulse control disorder (ICD) or dopamine dysregulation syndrome (DDS) in patients with Parkinson disease (PD). ICD/DDS is presumed to be related to dopaminergic treatment in...
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Determining Factors for the Reduction of Dopaminergic Drugs after Bilateral Subthalamic Nucleus Deep Brain Stimulation

Kim SR, Chung SJ, Lee TY, Kim MJ, Kim MS, Lee MC

  • KMID: 2343303
  • J Korean Neurol Assoc.
  • 2008 Feb;26(1):8-13.
BACKGROUND: We aimed to investigate the possible factors determining reduction of dopaminergic drugs in patients who received bilateral subthalamic nucleus (STN) deep brain stimulation (DBS). METHODS: We studied 33 consecutive Parkinson's...
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Protective Effects of K6PC-5, A Sphingosine Kinase Activator, Against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death

Jang S, Choi SS, Kim SH, Park JS, Jeong HS

Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metaolite, regulates multiple cellular responses such as Ca2+ signaling, cellular growth and survival, and differentiation. Sphingosine kinase (SphK) is a key enzyme in modulating the...
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A Case of Disseminated Polycystic Dilated Perivascular Spaces Presenting with Dementia and Parkinsonism

Kim DG, Oh SH, Kim OJ

The perivascular spaces (PVSs) of the brain are lined with pia and contain interstitial fluid. In general, PVSs are small, asymptomatic, and identifiable at all ages. When PVSs are significantly...
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Diagnosis and Treatment of Restless Leg Syndrome and Periodic Limb Movement of Sleep

Ham BJ

  • KMID: 2317387
  • Sleep Med Psychophysiol.
  • 2003 Jun;10(1):26-31.
Restless leg syndrome (RLS) and periodic limb movement of sleep (PLMS), often concurrent, come under diagnosed disorders of sleep and treatable condition. RLS symptoms are evoked in the limbs at...
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The use of Amantadine in Traumatic Brain Injury Patients

Jung HY, Kim YR

  • KMID: 2334634
  • J Korean Soc Biol Psychiatry.
  • 2000 Jul;7(1):55-63.
Avariety of symptoms can occur following traumatic brain injury(TBI) or other types of acquired brain injury. These symptoms can include problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition,...
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Neurobiological Pathophysiology of Attention Deficit Hyperactivity Disorder

Park HB, Joo Y

BACKGROUND: Models of attention deficit hyperactivity disorder(ADHD) that have proposed a hypodopaminergic state resulting in hypofunction of the prefrontal circuitry have assumed a unitary dopamine system, which largely ignores the...
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The effect of typical and atypical antipsychotic drugs on the mRNA expression of rat mesencephalic D2 receptor

Shon YH, Kim JS

  • KMID: 1536883
  • J Korean Neurol Assoc.
  • 1997 Oct;15(5):1022-1041.
Recently various types of dopamine receptors have been proved to exist in human central nervous system. And the understanding of the of specific function is expected to improve therapeutic effect...
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Striatal Network Model in Parkinson Disease: Preliminary Study

Choi KG, Park KD

OBJECTIVE: To construct the neural network model in the striatum that can explain the clin-ical effect of Parkinson disease. METHODS: We use an approach to studying the function of neural systems...
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Spasmodic torticollis: medical and botulinum A toxin treatment

Lee MC

The exact pathophysiologic mechanisms of spasmodic torticollis and other idiopathic torsion dystonias remain largely unknown. Thus, a variety of drugs have been used alone or in combination on an empirical...
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