J Korean Soc Biol Psychiatry.  2000 Jul;7(1):55-63.

The use of Amantadine in Traumatic Brain Injury Patients

• Jung HY
• Kim YR

Abstract

Avariety of symptoms can occur following traumatic brain injury(TBI) or other types of acquired brain injury. These symptoms can include problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition, poor motivation, and other behavioral and cognitive deficit. These symptoms may respond to certain drugs, such as dopaminergic agents. Amantadine may protect patients from secondary neuronal damage after brain injury as a effects of NMDA receptor antagonists and may improve functioning of brain-injured patients as a dopaminergic agonist. Clinically, based on current evidence, amantadine may provide a potentially effective, safe, and inexpensive option for treating the cognitive, mood and behavioral disorders of individuals with brain injury. The rationales for using amantadine are discussed, and pertinent literatures are reviewed.

MeSH Terms

Amantadine*
Brain
Brain Injuries*
Dopamine Agents
Dopamine Agonists
Humans
Impulsive Behavior
Memory, Short-Term
Motivation
N-Methylaspartate
Neurons
Problem Solving
Amantadine
Dopamine Agents
Dopamine Agonists
N-Methylaspartate