Hanyang Med Rev.  2013 Nov;33(4):216-220. 10.7599/hmr.2013.33.4.216.

Diagnosis and Treatment of Restless Legs Syndrome

• Jung KY

• KMID: 2284437
• DOI: http://doi.org/10.7599/hmr.2013.33.4.216

Abstract

Restless legs syndrome (RLS) is a sensorimotor neurologic disorder, in which the primary symptom is a compelling urge to move the legs accompanied by unpleasant and disturbing sensations in the legs. RLS is relatively common, affecting 2.5 to 15% of the general population, with prevalence rates increasing alongside age. Sleep disturbance is the most common symptom owing to RLS leg symptoms. In addition, daytime dysfunction, cognitive decline, and mood disturbance are also common in patients with RLS. Iron and dopamine are implicated in the pathophysiology of RLS, however, the underlying pathophysiology of RLS is still not fully understood. The diagnosis can be made based on the symptom characteristics, differential diagnosis is important because many conditions could mimic RLS symptoms. Dopaminergic agents are recommended for the first line treatment of RLS. Alpha2delta anticonvulsants such as gabapentin and pregabalin are also effective for controlling RLS symptoms.

Keyword

Restless Legs Syndrome; Diagnosis; Therapeutics; Dyssomnias

MeSH Terms

Amines
Anticonvulsants
Cyclohexanecarboxylic Acids
Diagnosis*
Diagnosis, Differential
Dopamine
Dopamine Agents
Dyssomnias
gamma-Aminobutyric Acid
Humans
Iron
Leg
Nervous System Diseases
Prevalence
Restless Legs Syndrome*
Sensation
Pregabalin
Amines
Anticonvulsants
Cyclohexanecarboxylic Acids
Dopamine
Dopamine Agents
Iron
gamma-Aminobutyric Acid

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