- GABAergic neuronal development in the embryonic mesencephalon of mice
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- KMID: 2470119
- Korean J Vet Res.
- 2019 Dec;59(4):201-205.
- doi: 10.14405/kjvr.2019.59.4.201
This study presents neurogenesis and neuronal migration patterns of gamma-aminobutyric acid-ergic (GABAergic) neurons during mesencephalic development of mouse. After neurons from embryonic day (E) 10-16 were labelled by a single... -
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- Glial Cell Line-derived Neurotrophic Factor-overexpressing Human Neural Stem/Progenitor Cells Enhance Therapeutic Efficiency in Rat with Traumatic Spinal Cord Injury
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Hwang K, Jung K, Kim IS, Kim M, Han J, Lim J, Shin JE, Jang JH, Park KI
- KMID: 2468885
- Exp Neurobiol.
- 2019 Dec;28(6):679-696.
- doi: 10.5607/en.2019.28.6.679
Spinal cord injury (SCI) causes axonal damage and demyelination, neural cell death, and comprehensive tissue loss, resulting in devastating neurological dysfunction. Neural stem/progenitor cell (NSPCs) transplantation provides therapeutic benefits for... -
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- Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats
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Kwon HH, Neupane C, Shin J, Gwon DH, Yin Y, Shin N, Shin HJ, Hong J, Park JB, Yi Y, Kim DW, Kang JW
- KMID: 2458550
- Exp Neurobiol.
- 2019 Aug;28(4):529-536.
- doi: 10.5607/en.2019.28.4.529
Stress can induce a serious epileptic encephalopathy that occurs during early infancy. Recent studies have revealed that prenatal stress exposure is a risk factor for the development of infantile spasms.... -
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- The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations
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Jung WY, Kim SG, Kim HK, Huh SY, Kim DW, Yoon DU, Yang CH, Kim HY, Jang EY
- KMID: 2456172
- Psychiatry Investig.
- 2019 Aug;16(8):615-620.
- doi: 10.30773/pi.2019.05.13.2
OBJECTIVE: Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is... -
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- The antinociceptive effect of artemisinin on the inflammatory pain and role of GABAergic and opioidergic systems
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Dehkordi F, Kaboutari , Zendehdel , Javdani M
- KMID: 2455611
- Korean J Pain.
- 2019 Jul;32(3):160-167.
- doi: 10.3344/kjp.2019.32.3.160
BACKGROUND: Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have... -
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- Dexmedetomidine and propofol sedation requirements in an autistic rat model
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Elmorsy SA, Soliman GF, Rashed LA, Elgendy H
- KMID: 2447512
- Korean J Anesthesiol.
- 2019 Apr;72(2):169-177.
- doi: 10.4097/kja.d.18.00005
BACKGROUND: Autism is a challenging neurodevelopmental disorder. Previous clinical observations have suggested altered sedation requirements for children with autism. Our study aimed to test this observation experimentally in an animal... -
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- Regional difference in spontaneous firing inhibition by GABA(A) and GABA(B) receptors in nigral dopamine neurons
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Kim Y, Jang J, Kim HJ, Park MK
- KMID: 2430095
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):721-729.
- doi: 10.4196/kjpp.2018.22.6.721
GABAergic control over dopamine (DA) neurons in the substantia nigra is crucial for determining firing rates and patterns. Although GABA activates both GABA(A) and GABA(B) receptors distributed throughout the somatodendritic... -
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- Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G(αs) Protein-coupled Receptor
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Lee N, Sa M, Hong YR, Lee CJ, Koo J
- KMID: 2424731
- Exp Neurobiol.
- 2018 Oct;27(5):365-376.
- doi: 10.5607/en.2018.27.5.365
Medium-chain fatty acids (MCFAs) are mostly generated from dietary triglycerides and can penetrate the blood-brain barrier. Astrocytes in the brain use MCFAs as an alternative energy source. In addition, MCFAs... -
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- Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-predominant Irritable Bowel Syndrome
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Aggarwal S, Ahuja V, Paul J
- KMID: 2417387
- J Neurogastroenterol Motil.
- 2018 Jul;24(3):422-430.
- doi: 10.5056/jnm17100
BACKGROUND/AIMS: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a prevalent functional bowel disorder. Abdominal pain, discomfort and altered intestinal habits are the salient features of IBS-D. Low grade inflammation and altered... -
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- Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial
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Byun JI, Shin YY, Chung SE, Shin WC
- KMID: 2415043
- J Clin Neurol.
- 2018 Jul;14(3):291-295.
- doi: 10.3988/jcn.2018.14.3.291
BACKGROUND AND PURPOSE: This study aimed to determine the subjective and objective improvements in sleep quality after treatment with gamma-aminobutyric acid (GABA; 300 mg daily) extracted from unpolished rice germ. METHODS:... -
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- Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems
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Hong KB, Park Y, Suh HJ
- KMID: 2442294
- Nutr Res Pract.
- 2018 Jun;12(3):208-214.
- doi: 10.4162/nrp.2018.12.3.208
BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the biological and sleep-promoting effects of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) using caffeine-induced sleepless fruit flies, ICR mice, and... -
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- Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus
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Chun H, An H, Lim J, Woo J, Lee J, Ryu H, Lee CJ
- KMID: 2416243
- Exp Neurobiol.
- 2018 Jun;27(3):155-170.
- doi: 10.5607/en.2018.27.3.155
Astrocytes are the most abundant cell type in the brain and they make close contacts with neurons and blood vessels. They respond dynamically to various environmental stimuli and change their... -
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- Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats
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Kwon HH, Lee T, Hong J, Kim DW, Kang JW
- KMID: 2412141
- Korean J Pediatr.
- 2018 May;61(5):150-155.
- doi: 10.3345/kjp.2018.61.5.150
PURPOSE: Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of... -
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- Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes
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Nam MH, Han KS, Lee J, Bae JY, An H, Park S, Oh SJ, Kim E, Hwang E, Bae YC, Lee CJ
- KMID: 2410473
- Exp Neurobiol.
- 2018 Apr;27(2):120-128.
- doi: 10.5607/en.2018.27.2.120
µ-opioid receptor (MOR) is a class of opioid receptors with a high affinity for enkephalins and beta-endorphin. In hippocampus, activation of MOR is known to enhance the neuronal excitability of... -
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- Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats
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Ju J, Shin JY, Yoon JJ, Yin M, Yoon MH
- KMID: 2436061
- Anesth Pain Med.
- 2018 Jan;13(1):82-92.
- doi: 10.17085/apm.2018.13.1.82
BACKGROUND: Curcumin is traditionally used as an herbal medicine. We explored the efficacy of intrathecal curcumin in relieving both postoperative and inflammatory pain and elucidated the mechanisms of action of... -
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- Physical Modeling of Chemical Exchange Saturation Transfer Imaging
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Jahng GH, Oh JH
- KMID: 2401374
- Prog Med Phys.
- 2017 Dec;28(4):135-143.
- doi: 10.14316/pmp.2017.28.4.135
Chemical Exchange Saturation Transfer (CEST) imaging is a method to detect solutes based on the chemical exchange of mobile protons with water. The solute protons exchange with three different patterns,... -
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- Reexamination of Dopaminergic Amacrine Cells in the Rabbit Retina: Confocal Analysis with Double- and Triple-labeling Immunohistochemistry
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Lee JW, Lim MY, Park YS, Park SJ, Kim IB
- KMID: 2398421
- Exp Neurobiol.
- 2017 Dec;26(6):329-338.
- doi: 10.5607/en.2017.26.6.329
Dopaminergic amacrine cells (DACs) are among the most well-characterized neurons in the mammalian retina, and their connections to AII amacrine cells have been described in detail. However, the stratification of... -
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- Developmental changes in GABAA tonic inhibition are compromised by multiple mechanisms in preadolescent dentate gyrus granule cells
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Pandit S, Lee GS, Park JB
- KMID: 2395265
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):695-702.
- doi: 10.4196/kjpp.2017.21.6.695
The sustained tonic currents (I(tonic)) generated by γ-aminobutyric acid A receptors (GABA(A)Rs) are implicated in diverse age-dependent brain functions. While various mechanisms regulating I(tonic) in the hippocampus are known, their... -
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- Production and Its Anti-hyperglycemic Effects of γ-Aminobutyric Acid from the Wild Yeast Strain Pichia silvicola UL6-1 and Sporobolomyces carnicolor 402-JB-1
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Han SM, Lee JS
- KMID: 2425135
- Mycobiology.
- 2017 Sep;45(3):199-203.
- doi: 10.5941/MYCO.2017.45.3.199
This study was done to produce γ-aminobutyric acid (GABA) from wild yeast as well as investigate its anti-hyperglycemic effects. Among ten GABA-producing yeast strains, Pichia silvicola UL6-1 and Sporobolomyces carnicolor... -
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- Association between GABA3 Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children
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Kwon HJ, Kim W, Lim MH
- KMID: 2395495
- Psychiatry Investig.
- 2017 Sep;14(5):693-697.
- doi: 10.4306/pi.2017.14.5.693
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is common disorder of the school-age population. ADHD is familial and genetic studies estimate heritability at 80–90%. The aim of the present study was... -
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