Investig Magn Reson Imaging.  2017 Jun;21(2):102-105. 10.13104/imri.2017.21.2.102.

Immediate Decrease in γ-AminoButyric Acid after Caffeine Intake in Adolescents: a Preliminary MRS Study

• Hahn S
• Kim YH
• Seo HS

• KMID: 2385607
• DOI: http://doi.org/10.13104/imri.2017.21.2.102

Abstract

In adolescents, sleep deprivation problem is getting worse, and increased caffeine consumption is considered to relieve the stress caused by sleep deprivation and academic burden. In this study, immediate neurologic effects of caffeine intake on adolescents were evaluated in three high school students using the γ-aminobutyric acid (GABA)/creatine ratio on magnetic resonance spectroscopy (MRS). MEGA-PRESS MRS and TE 135 ms single voxel MRS were performed in the anterior cingulate cortex before and after drinking a cup of coffee, which contained 104 mg of caffeine. GABA and creatine were measured on LCModel 6.3, respectively. In all three students, GABA/creatine ratios were decreased after caffeine intake. The GABA/creatine ratios obtained before caffeine intake were decreased after caffeine intake in all the three adolescents. In this preliminary study, caffeine intake caused an immediate decrease in the GABA/creatine ratio in the brain and it may be related to the neurologic effects of caffeine on an adolescent's brain.

Keyword

Gamma aminobutyric acid; Brain; Caffeine; Magnetic resonance spectroscopy

MeSH Terms

Adolescent*
Brain
Caffeine*
Coffee
Creatine
Drinking
gamma-Aminobutyric Acid
Gyrus Cinguli
Humans
Magnetic Resonance Spectroscopy
Sleep Deprivation
Caffeine
Coffee
Creatine
gamma-Aminobutyric Acid

Figure

• 

  Fig. 1. Measurement of the GABA/creatine ratio on brain MRS (Subject 1). (a) Brain MRS for measuring GABA at the anterior cingulate cortex. (b) GABA rate before caffeine intake. (c) GABA rate after caffeine intake. (d) Creatine before caffeine intake. (e) Creatine after caffeine intake.

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